68363-43-9

Upstream product

• 75-09-2 dichloromethane 
• 76-83-5 trityl chloride 
• 64987-08-2 ethyl 2-(2-aminothiazol-4-yl)glyoxylate 

Downstream Products

• 68363-44-0 2-oxo-2-(2-(tritylamino)thiazol-4-yl)acetic acid 
• 133076-31-0 p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(2-(3-diphenylmethoxy-4-pyridon-1-yl)-1-diphenylmethoxycarbonylethoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate 
• 133076-30-9 p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(3-(3-diphenylmethoxy-4-pyridon-1-yl)-3-diphenylmethoxycarbonylpropoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate 
• 133076-26-3 (Z)-2-(2-tritylaminothiazol-4-yl)-2-<2-(3-diphenylmethoxy-4-pyridon-1-yl)ethoxyimino>acetic acid 
• 138456-49-2 (Z)-2-(2-tritylaminothiazol-4-yl)-2-<2-(3-diphenylmethoxy-4-pyridon-1-yl)-1-diphenylmethoxycarbonylethoxyimino>acetic acid 
• 133076-23-0 (Z)-2-(2-tritylaminothiazol-4-yl)-2-<3-(3-diphenylmethoxy-4-pyridon-1-yl)-3-diphenylmethoxycarbonylpropoxyimino>acetic acid 
• 133076-32-1 p-methoxybenzyl 7-<(Z)-2-(2-tritylaminothiazol-4-yl)-2-(2-(3-diphenylmethoxy-4-pyridon-1-yl)ethoxyimino)acetamido>-3-(1,2,3-thiadiazol-5-yl)thiomethyl-3-cephem-4-carboxylate 
• 68672-50-4 2-(2-tritylaminothiazol-4-yl)-(Z)-2-(tert-butoxycarbonylmethoxyimino)acetic acid 

Relevant academic research and scientific papers

Synthesis and antibacterial evaluation against resistant Gram-negative bacteria of monobactams bearing various substituents on oxime residue

Based on the structural characteristics of aztreonam (AZN) and its target PBP3, a series of new monobactam derivatives bearing various substituents on oxime residue were prepared and evaluated for their antibacterial activities against susceptible and res

MONOCYCLIC B-LACTAM COMPOUND FOR TREATING BACTERIAL INFECTION

Disclosed are a class of new monocyclic β-lactam compounds, an isomer thereof or pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising the compounds, and the use of same in preparing drugs for treating diseases associated

DEUTERATED O-SULFATED BETA-LACTAM HYDROXAMIC ACIDS AND DEUTERATED N-SULFATED BETA-LACTAMS

Provided herein are deuterated O-sulfated beta-lactam hydroxamic acids and deuterated N-sulfated beta-lactams, pharmaceutical compositions thereof and methods of treating infectious disease with deuterated compounds or pharmaceutical compositions thereof.

Cephem derivative

Cephem derivatives of the general formula STR1 in which the R2 O group is in the syn-position, a process for their manufacture and pharmaceutical formulations which are active against bacterial infections and contain these compounds.