813433-73-7Relevant articles and documents
Organocatalytic enantioselective synthesis of quinolizidine alkaloids (+)-myrtine, (-)-lupinine, and (+)-epiepiquinamide
Fustero, Santos,Moscardó, Javier,Sánchez-Roselló, María,Flores, Sonia,Guerola, Marta,Pozo, Carlos Del
, p. 7412 - 7417 (2011/10/09)
The organocatalytic synthesis of quinolizidine alkaloids (+)-myrtine, (-)-lupinine, and (+)-epiepiquinamide is described. It involved, as the key step, an enantioselective intramolecular aza-Michael reaction (IMAMR) catalyzed by J?rgensen catalyst I, affording the common precursor with high enantioselectivity. This compound was subsequently transformed into the three alkaloids in a highly diastereoselective manner.
Chemoenzymatic approach to enantiopure piperidine-based β-amino esters in organic solvents
Liljeblad, Arto,Kavenius, Hanna-Maija,Taehtinen, Petri,Kanerva, Liisa T.
, p. 181 - 191 (2007/10/03)
This research concentrates on the enantioselectivities of lipase-catalysed reactions with methyl esters of 2-piperidylacetic acid and 3-piperidinecarboxylic acid derivatives. N-Acetylated 2-piperidylacetic acid methyl ester displayed good enantioselectivi
Enzymatic resolution of cyclic N-Boc protected β-aminoacids
Pousset, Cyrille,Callens, Roland,Haddad, Mansour,Larcheveque, Marc
, p. 3407 - 3412 (2007/10/03)
Methyl and ethyl esters of N-Boc homoproline, homopipecolic acid and 3-carboxymethyl-morpholine were kinetically resolved by hydrolysis catalysed by Burkholderia cepacia lipase to give the corresponding acids and residual esters in enantiomeric excesses better than 99% (E > 100).