6843-89-6Relevant academic research and scientific papers
Transition-Metal-Free Benzannulation of Tricarbonyl Derivatives with Arynes: Access to 1,3-Dinaphthol Precursors for the Synthesis of Rhodamine Dye Analogues
Ghotekar, Ganesh S.,Shaikh, Aslam C.,Muthukrishnan
, p. 2269 - 2276 (2019/05/16)
Herein, we report a transition-metal-free annulation reaction of benzynes and 1,3-oxopentanedioate for the synthesis of highly functionalized naphthalene derivatives for the first time. Additionally, the representative naphthalene derivatives have been successfully transformed into the new series of rhodamine dye analogues.
The Interrupted Pummerer Reaction in a Sulfoxide-Catalyzed Oxidative Coupling of 2-Naphthols
He, Zhen,Pulis, Alexander P.,Procter, David J.
supporting information, p. 7813 - 7817 (2019/05/15)
A benzothiophene S-oxide catalyst, generated in situ by sulfur oxidation with H2O2, mediates the oxidative coupling of 2-naphthols. Key to the catalytic process is the capture and inversion of reactivity of a 2-naphthol partner, using an interrupted Pummerer reaction of an unusual benzothiophene S-oxide, followed by subsequent coupling with a second partner. The new catalytic manifold has been showcased in the synthesis of the bioactive natural products, (±)-nigerone and (±)-isonigerone. Although Pummerer reactions are used widely, their application in catalysis is rare, and our approach represents a new catalytic manifold for metal-free C?C bond formation.
Comprehensive study on excited state intramolecular proton transfer in 2-(benzo[d]thiazol-2-yl)-3-methoxynaphthalen-1-ol and 2-(benzo[d]thiazol-2-yl)naphthalene-1,3-diol: Effect of solvent, aggregation, viscosity and TDDFT study
Warde, Umesh,Nagaiyan, Sekar
, p. 33 - 43 (2017/01/28)
Three compounds DMT, MMT and DHT having dimehtoxy, mono-hydroxy and di-hydroxy groups respectively were prepared. Environmental interactions dependent photophysical properties especially excited state intramolecular proton transfer (ESIPT), solvatochromism, aggregation induced emission enhancement (AIEE) and viscosity dependent emission characteristics were studied. The effect of solvent polarity on ESIPT dynamics were studied using UV–vis and emission spectroscopy along with aggregation induced enhanced emission and viscosity effect. MMT and DHT showed unexpected and contrasting behavior in the solvents which are in good agreement with the density functional theory and time dependent density functional theory findings. Aggregation and viscosity study showed that cis-keto emission increased drastically in the aggregate state and highly viscous state due to restricted intramolecular rotation increasing the population of required cis enol rotamer (E). The study directs the potential applications of such molecules for advanced optoelectronics and viscosity based investigations.
Novel Inhibitors of Hepatitis C Virus Replication
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Page/Page column 52-53, (2009/10/21)
The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
