685895-63-0

Upstream product

• 7149-92-0 2,4-dimethoxy-3-methylbenzaldehyde 
• 685895-47-0 acetic acid acetoxy-(3-amino-2-bromo-4,6-dimethoxy-5-methyl-phenyl)-methyl ester 
• 685895-46-9 acetic acid acetoxy-(2,4-dimethoxy-3-methyl-5-nitro-phenyl)-methyl ester 
• 685895-48-1 6-bromo-2,4-dimethoxy-3-methylbenzaldehyde 
• 685895-45-8 2-bromo-4,6-dihydroxy-5-methylbenzaldehyde 

Relevant academic research and scientific papers

Synthesis of azaphilones and related molecules by employing cycloisomerization of o-alkynylbenzaldehydes

Right to the core: Gold(III)-catalyzed cycloisomerization of o-alkynylbenzaldehydes to 2-benzopyrylium salts and subsequent in situ oxidation have been employed to prepare the core structure of azaphilone natural products, such as the sphingosine kinase inhibitor S-15183 (see scheme, DCE = 1,2-dichloroethane, TFA = trifluoroacetic acid)), and several unnatural azaphilones.