6860-95-3

Upstream product

• 14005-14-2 2,2-dimethyl-1,3-benzodioxole 
• 75-36-5 acetyl chloride 
• 108-24-7 acetic anhydride 
• 1197-09-7 1-(3,4-dihydroxyphenyl)ethan-1-one 
• 67-64-1 acetone 

Downstream Products

• 421572-98-7 2-((2-(3,4-dihydroxyphenyl)-2-oxoethyl)thio)quinazolin-4(3H)-one 
• 1380732-71-7 1-(2,2-dimethylbenzo[d][1,3]dioxol-5-yl)-2-phenoxyethanone 
• 1380732-75-1 1-(2,2-dimethylbenzo[d][1,3]dioxol-5-yl)-2-(phenylthio)ethanone 
• 1380732-76-2 1-(2,2-dimethylbenzo[d][1,3]dioxol-5-yl)-2-(3-(trifluoromethyl)phenoxy)ethanone 
• 1380732-79-5 1-(2,2-dimethylbenzo[d][1,3]dioxol-5-yl)-2-(2-fluorophenoxy)ethanone 
• 1380732-80-8 1-(2,2-dimethylbenzo[d][1,3]dioxol-5-yl)-2-(3-nitrophenoxy)ethanone 
• 1380732-85-3 1-(2,2-dimethylbenzo[d][1,3]dioxol-5-yl)-2-(2-(isoxazol-5-yl)phenoxy)ethanone 
• 1380732-88-6 1-(2,2-dimethylbenzo[d][1,3]dioxol-5-yl)-2-(2-(trifluoromethyl)phenylthio)ethanone 
• 1380732-91-1 1-(2,2-dimethylbenzo[d][1,3]dioxol-5-yl)-2-((4-fluorophenyl)thio)ethanone 
• 1380732-94-4 2-((4-chlorophenyl)thio)-1-(2,2-dimethylbenzo[d][1,3]dioxol-5-yl)ethanone 
• 1380732-97-7 1-(2,2-dimethylbenzo[d][1,3]dioxol-5-yl)-2-((4,5-diphenyloxazol-2-yl)thio)ethanone 
• 1380732-72-8 1-(3,4-dihydroxyphenyl)-2-phenoxyethanone 
• 131985-77-8 1-(3,4-dihydroxyphenyl)-2-(phenylthio)ethanone 
• 1380733-04-9 1-(3,4-dihydroxyphenyl)-2-(3-(trifluoromethyl)phenoxy)ethanone 

Relevant academic research and scientific papers

Elucidation of Mycobacterium tuberculosis TypeII Dehydroquinase Inhibitors using a Fragment Elaboration Strategy

A library of novel Mycobacterium tuberculosis typeII dehydroquinase (DHQase) inhibitors were discovered through the use of a fragment elaboration approach. Putative active site binding fragments were initially assessed insilico which led to the selection of two small aromatic fragments for further investigation. Synthetic elaboration of the fragments provided a library of 34 inhibitors that exhibited low-micromolar inhibition of typeII DHQase. A number of these inhibitors also showed antibacterial activity in the low-micromolar range in screens against M. tuberculosis invitro; these now serve as lead compounds for further development of therapeutics for the treatment of tuberculosis.

Synthesis of podophyllotoxin and related analogues: Part X - Tetralone esters as intermediates for synthesis of analogues of β-apopicropodophyllin

3-Ethylcarboxy-4-trimethoxyphenyl-6,7-dimethyl-methylenedioxy-1- tetralone 5 and 3-ethyl carboxy-4-trimethoxy phenyl-6,7-ethyl methyl- methylenedioxy-1-tetralone 6, intermediates for the synthesis of analogues 3 and 4 respectively of β-apopicropodophyllin

Studies on the Synthesis of Heterocyclic Compounds. XVI. Cleavage of 1,3-Benzodioxoles and -Benzoxathioles by Sodium Iodide-Acyl Chloride

The cleavage reaction of ethereal and thioethereal bonds with sodium iodide and acyl chloride has been studied.In all the 1,3-benzodioxoles and -benzoxathioles studied, the opening of the heterocyclic ring with formation of 1,2-diacetoxybenzene or 2-hydroxythiophenol diacetic acid ester and gem-diiodoalkanes and iodoalkenes has been observed.The structure of newly prepared compounds has been determined by analytical and spectroscopic data or comparison with authentic samples.