68642-58-0Relevant articles and documents
Design and synthesis of dansyl-labeled inhibitors of steroid sulfatase for optical imaging
Barbeau, Xavier,Lambert, Jean-Philippe,Ngueta Djiemeny, Adrien,Poirier, Donald,Roy, Jenny,Maltais, René
, (2020)
Steroid sulfatase (STS) is an important enzyme regulating the conversion of sulfated steroids into their active hydroxylated forms. Notably, the inhibition of STS has been shown to decrease the levels of active estrogens and was translated into clinical t
Synthesis of steroidal nitrosoureas with antitumor activity
Lam,Begleiter,Goldenberg,Wong
, p. 200 - 202 (1979)
Four steroidal nitrosoureas with structures which may permit specific binding to estrogen receptor were synthesized. Inhibitory activity was observed against the growth of the DMBA-induced transplantable rat mammary tumor 13762.
Synthesis of unprecedented steroidal spiro heterocycles as potential antiproliferative drugs
Romero-Hernández, Laura L.,Merino-Montiel, Penélope,Meza-Reyes, Socorro,Vega-Baez, José Luis,López, óscar,Padrón, José M.,Montiel-Smith, Sara
, p. 21 - 32 (2017/11/24)
Herein we report the straightforward preparation of novel conformationally-restricted steroids from trans-androsterone and estrone, decorated with spiranic oxazolidin-2-one or 2-aminooxazoline motifs at C-17 as potential antiproliferative agents. Such unp