68758-69-0Relevant articles and documents
Synthesis method 2- hydroxyl carboxylic ester (by machine translation)
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Paragraph 0052; 0054; 0055; 0058-0060, (2020/05/05)
The method, is simple 2 - energy consumption, energy consumption is low, the production :(1) of waste water can be greatly reduced, the yield of the target product is high 2 - and the production cost ;(2) is greatly reduced (1). 2 - The method comprises the following steps, preparing 2 - hydroxycarboxylate, with an acid ;(3) by a byproduct ammonium salt (2) in step, and filtering the excess acid, to remove the byproduct ammonium salt, to obtain 2 - hydroxyl carboxylic acid ester product, by esterification reaction in step (, and filtering to remove 2 - the excess, alcohol), from, the reaction, solution obtained by the reaction solution; of the catalyst under the, action of, a catalyst, to obtain the product of the compound. (by machine translation)
One-pot, diversity-oriented synthesis of aryl-substituted benzoxacycles including benzofuran, coumarin, and benzoxazepine
Masui, Hisashi,Ohkawa, Eri,Kitahara, Rika,Wanibuchi, Kiyofumi,Takahashi, Takashi
, p. 2273 - 2290 (2017/12/12)
A one-pot method for the synthesis of benzoxacycles including benzofuran, coumarin, benzoxazepine, and benzoxazocine from a common synthetic intermediate was established. Benzoxacycles are privileged structures in medicinal chemistry and have featured in several clinically used drugs. The synthesis of a benzofuran containing an aryl substituent was accomplished using potassium carbonate and sodium hydride. The one-pot synthesis of coumarin was also carried out using trans-decalin as the solvent. The optimized conditions for the one-pot synthesis of benzoxazepine can also be applied to the synthesis of benzoxazocine.
MANDELIC ACID DERIVATIVES AND PREPARATION THEREOF
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Page/Page column 14, (2008/12/05)
The invention relates to compounds, compositions, methods of using and processes for producing optically active α-hydroxy derivatives using a combination of a chemical and biochemical methods. The process comprises reacting an ester compound with a racemic compound in the presence of an enzyme to obtain compounds (compositions and methods). The compounds produced may be useful for starting materials for physiologically active materials, functional materials and the like.