6878-08-6Relevant academic research and scientific papers
Rat small intestine muscle relaxation alkaloids from Orixa japonica leaves
Funayama, Shinji,Tanaka, Rioko,Kumekawa, Yasuhiro,Noshita, Toshiro,Mori, Tetsuya,Kashiwagura, Tadashi,Murata, Kiyoshi
, p. 100 - 102 (2001)
Two quinoline alkaloids, japonine (1) and eduline (2) were isolated from the methanol extract of the leaves of Orixa japonica as relaxants against rat small intestine muscle. The activity of these alkaloids was comparable to that of the typical muscle rel
Direct Synthesis of 4-Quinolones via Copper-Catalyzed Anilines and Alkynes
Xu, Xuefeng,Zhang, Xu
supporting information, p. 4984 - 4987 (2017/09/22)
A unique and direct approach for constructing 4-quinolones from simple and readily available anilines and alkynes is described. Under the optimal conditions, both N-alkyl- and N-aryl-substituted anilines can be successfully transformed into the corresponding 4-quinolones. This reaction is characterized by mild reaction conditions, high functional-group tolerance, and amenability to gram-scale synthesis.
Short step synthesis of natural 2-arylquinolones based on iridium-catalyzed three-component coupling quinoline synthesis
Nakajima, Takayuki,Inada, Takashi,Shimizu, Isao
, p. 497 - 504 (2008/02/03)
Eduline (la), graveoline (1b), and 6-methoxy-2-(4-methoxyphenyl)-1-methylquinolone (1c) were synthesized by iridium-catalyzed three-component coupling reaction. Reaction of an aniline, an aromatic aldehyde, and acetaldehyde gave the corresponding substitu
Synthesis of 2-arylquinoline and 2-aryl-4-quinolone alkaloids via Diels- Alder reaction of 1,2,3-benzotriazine with enamines
Koyama, Junko,Toyokuni, Izumi,Tagahara, Kiyoshi
, p. 1038 - 1039 (2007/10/03)
Synthesis of the 2-arylquinoline alkaloids, 2-phenylquinoline and dubamine, and the 2-arylquinolone alkaloids, 1-methyl-2-phenyl-4-quinolone, graveoline, reevesianine-A, and eduline, was accomplished by the Diels-Alder reaction of 1,2,3-benzotriazine with enamines as a key step.
The Chemistry of 2H-3,1-Benzoxazine-2,4(1H)-dione (Isatoic Anhydride). 9. Synthesis of 2-Arylquinoline Alkaloids
Coppola, Gary M.
, p. 727 - 731 (2007/10/02)
A one-step synthesis of N-methyl-2-aryl-4-quinolone alkaloids is described.These compounds are readily prepared from the reaction of an N-methylisatoic anhydride with the lithium enolate of an acetophenone.By this method, the reaction of N-methylisatoic a
