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N-[4-(methylsulfamoyl)phenyl]acetamide is a chemical compound with the molecular formula C9H12N2O3S. It is an amide derivative, characterized by the presence of an amide group (-CO-NH2) attached to a phenyl ring. The phenyl ring is substituted with a methylsulfamoyl group (-SO2NHCH3) at the para position (4th position). N-[4-(methylsulfamoyl)phenyl]acetamide is known for its potential applications in pharmaceuticals and agrochemicals, particularly as a building block for the synthesis of various active ingredients. It is also recognized for its role in the development of new drugs and pesticides, thanks to its unique chemical structure that can be further modified to create a range of derivatives with different biological activities.

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  • 6884-87-3 Structure
  • Basic information

    1. Product Name: N-[4-(methylsulfamoyl)phenyl]acetamide
    2. Synonyms: acetamide, N-[4-[(methylamino)sulfonyl]phenyl]-
    3. CAS NO:6884-87-3
    4. Molecular Formula: C9H12N2O3S
    5. Molecular Weight: 228.2682
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 6884-87-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: 1.318g/cm3
    6. Refractive Index: 1.57
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-[4-(methylsulfamoyl)phenyl]acetamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-[4-(methylsulfamoyl)phenyl]acetamide(6884-87-3)
    11. EPA Substance Registry System: N-[4-(methylsulfamoyl)phenyl]acetamide(6884-87-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 6884-87-3(Hazardous Substances Data)

6884-87-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 6884-87-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,8,8 and 4 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 6884-87:
(6*6)+(5*8)+(4*8)+(3*4)+(2*8)+(1*7)=143
143 % 10 = 3
So 6884-87-3 is a valid CAS Registry Number.

6884-87-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[4-(methylsulfamoyl)phenyl]acetamide

1.2 Other means of identification

Product number -
Other names 4-acetamido-N-methylbenzenesulphonamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6884-87-3 SDS

6884-87-3Relevant articles and documents

Effect of photodynamic antibacterial chemotherapy combined with antibiotics on Gram-positive and gram-negative bacteria

Ilizirov, Yana,Formanovsky, Andrei,Mikhura, Irina,Paitan, Yossi,Nakonechny, Faina,Nisnevitch, Marina

, (2018/12/11)

The well-known and rapidly growing phenomenon of bacterial resistance to antibiotics is caused by uncontrolled, excessive and inappropriate use of antibiotics. One of alternatives to antibiotics is Photodynamic Antibacterial Chemotherapy (PACT). In the present study, the effect of PACT using a photosensitizer Rose Bengal alone and in combination with antibiotics including methicillin and derivatives of sulfanilamide synthesized by us was tested against antibiotic-sensitive and antibiotic-resistant clinical isolates of Gram-positive S. aureus and Gram-negative P. aeruginosa. Antibiotic-sensitive and resistant strains of P. aeruginosa were eradicated by Rose Bengal under illumination and by sulfanilamide but were not inhibited by new sulfanilamide derivatives. No increase in sensitivity of P. aeruginosa cells to sulfanilamide was observed upon a combination of Rose Bengal and sulfanilamide under illumination. All tested S. aureus strains (MSSA and MRSA) were effectively inhibited by PACT. When treated with sub-MIC concentrations of Rose Bengal under illumination, the minimum inhibitory concentrations (MIC) of methicillin decreased significantly for MSSA and MRSA strains. In some cases, antibiotic sensitivity of resistant strains can be restored by combining antibiotics with PACT.

Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors

Barbosa, Maria Letícia De Castro,Lima, Lídia Moreira,Tesch, Roberta,Sant'Anna, Carlos Mauricio R.,Totzke, Frank,Kubbutat, Michael H.G.,Sch?chtele, Christoph,Laufer, Stefan A.,Barreiro, Eliezer J.

, p. 1 - 14 (2013/12/04)

Novel 2-chloro-4-anilino-quinazolines designed as EGFR and VEGFR-2 dual inhibitors were synthesized and evaluated for inhibitory effects. EGFR and VEGFR-2 are validated targets in cancer therapy and combined inhibition might be synergistic for both antitumor activity and resistance prevention. The biological data obtained proved the potential of 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors, highlighting compound 8o, which was approximately 7-fold more potent on VEGFR-2 and approximately 11-fold more potent on EGFR compared to the prototype 7. SAR and docking studies allowed the identification of pharmacophoric groups for both kinases and demonstrated the importance of a hydrogen bond donor at the para position of the aniline moiety for interaction with conserved Glu and Asp amino acids in EGFR and VEGFR-2 binding sites.

A facile and efficient method for the selective deacylation of N-arylacetamides and 2-chloro-Narylacetamides catalyzed by SOCl2

Wang, Gong-Bao,Wang, Lin-Fa,Li, Chao-Zhang,Sun, Jing,Zhou, Guang-Ming,Yang, Da-Cheng

experimental part, p. 77 - 89 (2012/05/20)

Thionyl chloride efficiently and selectively promoted the deacylation of N-arylacetamides and 2-chloro-N-arylacetamides, under anhydrous conditions, without effecting the ester group, aminosulfonyl group, or benzyloxyamide group. This method, which has been successfully applied to a variety of substrates including different N-arylacetamides and 2-chloro-N-arylacetamides, has the attractive advantages of inexpensive reagents, satisfactory selectivity, excellent yields, short reaction time, and convenient workup. This new method can probably be used to selectively deacylate between aromatic amides and alkyl amides. Springer Science+Business Media B.V. 2011.

SUBSTITUTED CINNAMIC, ACID GUANIDIDES, PROCESS FOR THEIR PREPARATION, THEIR USE AS A MEDICAMENT, AND MEDICAMENT COMPRISING THEM

-

, (2008/06/13)

Substituted cinnamic acid guanidides, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them. Compounds of the 1, which may be obtained by reaction of a compound II 2with guanidine.

Matrix metalloprotease inhibitors

-

, (2008/06/13)

Compounds of formula (I) and their pharmaceutically acceptable salts inhibit matrix metalloproteases, such as stromelysin, gelatinase, matrilysin and collagenase, and are useful in the treatment of mammals having disease-states alleviated by the inhibition of such matrix metalloproteases.

Herbicidally active phenoxyalkanecarboxylic acid derivatives

-

, (2008/06/13)

A compound of the formula: STR1 wherein Q1 is CH or N; R is H or C1 -C5 alkyl; X is H, halogen, CF3, or NO2 ; Y is H or halogen; Z is --O-- or --NH--; A is STR2 wherein Q2, and Q3 are each CH or N; R1 and R2 are each H, C1 -C5 alkyl, C1 -C5 alkoxy, or C2 -C6 alkxoycarobnyl; R3, R4, and R5 are each H or C1 -C5 alkyl; R6 is H, halogen, or C1 -C5 alkyl; R7, R8, R9, and R10 are each H or C1 -C5 alkyl; R11 is H, C1 -C5 alkyl, C1 -C5 alkoxy, C2 -C6 alkenyl, C6 -C10 aryl, C7 -C15 aryloxyalkyl, or C7 -C15 aralkyl; R12 and R13 are each H or C1 -C5 alkyl; R14 is C1 -C5 alkyl, C2 -C6 alkenyl, C5 -C10 aryl, or C7 -C15 aralkyl; or R13 and R14 taken together form C3 -C4 alkylene, V1 and V2 are each H, halogen, NO2, CN, or CF3 ; V3 is halogen or CF3 ; W1 is --O-- or --NH--; W2 is --(CH2)n -- wherein n is 0 or 1, or CO; X1 is halogen, or a salt thereof, which is effective as a herbicidal agent.

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