1709-52-0

Basic information

• Product Name: 4-AMINO-N-METHYL-BENZENESULFONAMIDE
• Synonyms: n(sup1)-methylsulfanilamide;AKOS BBS-00000283;AKOS B000457;4-AMINO-N-METHYL-BENZENESULFONAMIDE;IFLAB-BB F1591-0157;BUTTPARK 34\07-93;ART-CHEM-BB B000457;N1-METHYLSULPHANILAMIDE
• CAS NO: 1709-52-0
• Molecular Formula: C₇H₁₀N₂O₂S
• Molecular Weight: 186.23
• Mol File: 1709-52-0.mol
• Article Data: 18

Chemical Properties

• Melting Point: 111 °C
• Boiling Point: 359.2°Cat760mmHg
• Flash Point: 171°C
• Appearance: /
• Density: 1.2900 (rough estimate)
• Vapor Pressure: 2.42E-05mmHg at 25°C
• Refractive Index: 1.5400 (estimate)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 12.38±0.30(Predicted)
• Water Solubility: 17.6g/L(37 oC)
• CAS DataBase Reference: 4-AMINO-N-METHYL-BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-N-METHYL-BENZENESULFONAMIDE(1709-52-0)
• EPA Substance Registry System: 4-AMINO-N-METHYL-BENZENESULFONAMIDE(1709-52-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• RTECS: WP0670000
• HazardClass: IRRITANT
• Hazardous Substances Data: 1709-52-0(Hazardous Substances Data)

Usage

Chemical Properties

Off-white to grey crystal or powder

Synthesis Reference(s)

The Journal of Organic Chemistry, 21, p. 1198, 1956 DOI: 10.1021/jo01116a029

InChI:InChI=1/C7H10N2O2S/c1-9-12(10,11)7-4-2-6(8)3-5-7/h2-5,9H,8H2,1H3

Upstream product

• 860425-08-7 N-methyl-N'-(4-methylsulfamoyl-phenyl)-succinamide 
• 68-35-9 sulfadiazine 
• 67-56-1 methanol 
• 63-74-1 sulfanilamide 
• 6319-45-5 N-methyl-4-nitro-benzenesulfonamide 
• 7440-02-0 nickel 
• 98-62-4 4-aminobenzenesulfonyl fluoride 
• 74-89-5 methylamine 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 6884-87-3 N-methyl-4-(acetamido)benzenesulfonamide 
• 103-84-4 Acetanilid 
• 62-53-3 aniline 

Downstream Products

• 146447-87-2 N-acryloyl-sulfanilic acid methylamide 
• 71119-14-7 N-(N-acetyl-sulfanilyl)-sulfanilic acid methylamide 
• 18101-53-6 6-(N-Methyl-sulfamoyl)-2-amino-benzthiazol 
• 18101-58-1 2-amino-benzothiazole-6-sulfonic acid amide 
• 1709-59-7 4-amino-N,N-dimethylbenzenesulphonamide 

Relevant articles and documents

NLRP MODULATORS

In one aspect, compounds of Formula AA, or a pharmaceutically acceptable salt thereof, are featured: or a pharmaceutically acceptable salt thereof, wherein the variables shown in Formula A can be as defined anywhere herein.

Effect of photodynamic antibacterial chemotherapy combined with antibiotics on Gram-positive and gram-negative bacteria

The well-known and rapidly growing phenomenon of bacterial resistance to antibiotics is caused by uncontrolled, excessive and inappropriate use of antibiotics. One of alternatives to antibiotics is Photodynamic Antibacterial Chemotherapy (PACT). In the present study, the effect of PACT using a photosensitizer Rose Bengal alone and in combination with antibiotics including methicillin and derivatives of sulfanilamide synthesized by us was tested against antibiotic-sensitive and antibiotic-resistant clinical isolates of Gram-positive S. aureus and Gram-negative P. aeruginosa. Antibiotic-sensitive and resistant strains of P. aeruginosa were eradicated by Rose Bengal under illumination and by sulfanilamide but were not inhibited by new sulfanilamide derivatives. No increase in sensitivity of P. aeruginosa cells to sulfanilamide was observed upon a combination of Rose Bengal and sulfanilamide under illumination. All tested S. aureus strains (MSSA and MRSA) were effectively inhibited by PACT. When treated with sub-MIC concentrations of Rose Bengal under illumination, the minimum inhibitory concentrations (MIC) of methicillin decreased significantly for MSSA and MRSA strains. In some cases, antibiotic sensitivity of resistant strains can be restored by combining antibiotics with PACT.