68877-57-6

Upstream product

• 79-01-6 Trichloroethylene 
• 108-93-0 cyclohexanol 
• 75-77-4 chloro-trimethyl-silane 
• 309263-55-6 (E)-1-Bromo-1-methoxy-4-methyl-pent-1-ene 
• 442631-19-8 (3S,8R,9S,10R,13S,14S)-3-(tert-Butyl-dimethyl-silanyloxy)-17-eth-(Z)-ylidene-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,17-tetradecahydro-cyclopenta[a]phenanthren-16-one 
• 1379419-62-1 O-cyclohexyl-1,2-dichloroenol ether 

Downstream Products

• 129193-93-7 C₁₆H₂₂O₂ 
• 162744-90-3 1-Benzyloxy-5-cyclohexyloxy-pent-4-yn-2-ol 
• 212891-60-6 ((E)-1-Methyl-penta-1,4-dienyloxy)-cyclohexane 
• 335197-14-3 (4-methyl-pent-1-ynyloxy)-cyclohexane 
• 566151-30-2 (+/-)-4-[(tert-butyl)dimethylsiloxy]-1-cyclohexyloxy-7-(trimethylsilyl)-1,6-heptadiyne 
• 1620066-61-6 4-(cyclohexyloxy)-1-(methylsulfonyl)-1H-1,2,3-triazole 
• 332888-23-0 Acetic acid (3S,8R,9S,10R,13S,14S)-3-(tert-butyl-dimethyl-silanyloxy)-17-((Z)-(R)-2-cyclohexyloxy-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-16-yl ester 
• 335197-18-7 Acetic acid (3S,8R,9S,10R,13S,14S)-3-(tert-butyl-dimethyl-silanyloxy)-17-((Z)-(S)-2-cyclohexyloxy-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-16-yl ester 
• 335197-16-5 ((E)-1-Bromo-4-methyl-pent-1-enyloxy)-cyclohexane 
• 332888-22-9 (3S,8R,9S,10R,13S,14S)-3-(tert-Butyl-dimethyl-silanyloxy)-17-((Z)-(R)-2-cyclohexyloxy-1,5-dimethyl-hex-2-enyl)-10,13-dimethyl-16-trimethylsilanyloxy-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthrene 
• 14352-61-5 methyl cyclohexylacetate 
• 108-93-0 cyclohexanol 
• 162744-91-4 (E)-1-Benzyloxy-5-cyclohexyloxy-pent-4-en-2-ol 

Relevant academic research and scientific papers

Asymmetric addition of alkoxy ethynyl anion to chiral N-sulfinyl imines

The addition of lithiated ynol ethers to chiral N-sulfinyl imines proceeds in high yield and diastereoselectivity. The selectivity is completely reversed by the addition of boron trifluoride. These alkoxypropargyl sulfinamides can be reduced to afford eno

Nickel-catalyzed [3+2+2] cycloaddition of ethyl cyclopropylideneacetate and heteroatom-substituted alkynes: Application to selective three-component reaction with 1,3-diynes

(Chemical Equation Presented) Heteroatom-substituted alkynes such as ynol ethers and ynamines turned out to be decent substrates for the Nicatalyzed [3 + 2 + 2] cocyclization of ethyl cyclopropylideneacetate (1). The three-component cocyclization of 1, 1,

Total synthesis of the anticancer natural product OSW-1

The highly potent anticancer natural saponin OSW-1 has been successfully synthesized from commercially available 5-androsten-3β-ol-17-one 79 in 10 operations with 28% overall yield. The key steps in the total synthesis included a highly regio- and stereoselective selenium dioxide-mediated allylic oxidation of 80 and a highly stereoselective 1,4-addition of α-alkoxy vinyl cuprates 68 to steroid 17(20)-en-16-one 12E to introduce the steroid side chain. This total synthesis demonstrated once again the versatile synthetic applications of α-halo vinyl ether chemistry developed in our laboratories.

Tandem Inter [4 + 2]/Intra [3 + 2] Cycloadditions of Nitroalkenes. the Bridged Mode (β-Tether)

A new variation of the tandem inter [4 + 2]/intra [3 + 2] cycloaddition of nitroalkenes has been developed. This method involves the Lewis acid-promoted [4 + 2] cycloaddition of nitro olefins 12 with 1-alkoxy-1,4-dienes 3. The resulting nitronates 13, bearing a C(5) tethered dipolarophile, undergo thermal, intramolecular [3 + 2] cycloaddition to afford stable tricyclic nitroso acetals 14, which can be subsequently reduced to unveil a new carbocycle 16, Thus, in three steps, highly functionalized aminocyclopentanes can be stereoselectively constructed in high yield.

The photochemistry of acetylenic ethers. A novel carbon-oxygen to carbon-carbon bond conversion

Irradiation of acetylenic ethers in methanol gives homologated esters via a formal [1,3]-oxygen-to-carbon migration involving a ketene intermediate.