69022-52-2Relevant academic research and scientific papers
HETEROAROMATIC MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA
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Page/Page column 38; 39; 46; 47, (2018/03/28)
The present invention relates to a compound according to general formula (I) wherein X represents N or CH; R1 is -CN, (C1-C6)alkyl, (C3-C7)cycloalkyl, (3-7 membered)heterocycloalkyl, (5-6 membered)heteroaryl, (C3-C7)cycloalkyl(C1-C4)alkyl, (3-7 membered)heterocycloalkyl-(C1-C4)alkyl or (5-6 membered)heteroaryl- (C1-C4)alkyl; R2 is halogen, cyano, (C1-C4)alkyl or (C3-C7)cycloalkyl; R3 is halogen, cyano, (C1-C4)alkyl, (C1-C4)haloalkyl or (C3-C7)cycloalkyl; R4 is (C1-C4)alkyl or (C1-C4)haloalkyl; R5 is (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkyl-(C3-C7)cycloalkyl, (C3-C7)cycloalkyl-(C1-C6)alkyl, (3-7 membered)heterocycloalkyl, phenyl, (5-6 membered)heteroaryl or -ORa. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds and to intermediates for preparation of said compounds.
Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay
Gotham, Victoria J. B.,Hobbs, Melanie C.,Burgin, Ryan,Turton, David,Smythe, Carl,Coldham, Iain
supporting information, p. 1559 - 1563 (2016/02/10)
During efforts to prepare the known compound NMDI1, a new tetracyclic compound, called VG1, was prepared in six steps. This compound was found to have good activity as an inhibitor of nonsense-mediated mRNA decay.
INHIBITORS OF DNA GYRASE FOR THE TREATMENT OF BACTERIAL INFECTIONS
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, (2014/05/07)
The present invention relates to compounds which specifically inhibit bacterial DNA Gyrase and can be used for the treatment of respiratory tract infections.
4-Imidazole derivatives of benzyl and restricted benzyl sulfonamides, sulfamides, ureas, carbamates, and amides and their use
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, (2008/06/13)
Compounds of formula I are useful in treating diseases prevented by or ameliorated with α1A agonists. Also disclosed are α1A agonist compositions and a method of activating α1 adrenoceptors in a mammal.
Dipyrido [4,3-b] [3,4-f] indoles and process for obtaining them
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, (2008/06/13)
The invention relates to compounds of formula: STR1 wherein R'1 =H, OH or an alkyl group, preferably a lower alkyl group, alkylthio or alkoxy, an halogen or an amino group, R'2 =H or a lower alkyl group. These compounds have antitumoral and antiviral properties useful for the treatment of cancers.
Photocyclization of 1-(1-Chloroisoquinolin-6-yl)-1H-v-triazolopyridines to 10-Chloro-5H-pyridopyrroloisoquinolines (Azaellipticines)
Rivalle, Christian,Ducrocq, Claire,Lhoste, Jean-Marc,Bisagni, Emile
, p. 2176 - 2180 (2007/10/02)
Whereas thermal cyclization of 1-(5,8-dimethyl-1-oxo-1,2-dihydroisoquinolin-6-yl)-1H-v-triazolopyridine affords 6,11-dimethyl-5H-pyridopyrroloisoquinolin-10(9H)-one which cannot be chlorinated to the corresponding chloro derivativ
