69113-60-6Relevant academic research and scientific papers
Preparation of Deuterium Labeled Compounds by Pd/C-Al-D2O Facilitated Selective H-D Exchange Reactions
Kadish, Dora,Kokel, Anne,T?r?k, Béla
supporting information, (2022/01/24)
The chemo/regioselective H-D exchange of amino acids and synthetic building blocks by an environmentally benign Pd/C-Al-D2O catalytic system is described. Due to the importance of isotope labeled compounds in medicinal chemistry and structural biology, no
Synthesis of Nonproteinogenic (R)- or (S)-Amino Acids. - Analogues of Phenylalanine, Isotopically Labelled and Cyclic Amino Acids from tert-Butyl 2-(tert-Butyl)-3-methyl-4-oxo-1-imidazolidinecarboxylate (Boc-BMI)
Seebach, Dieter,Dziadulewicz, Edward,Behrendt, Linda,Cantoreggi, Sergio,Fitzi, Robert
, p. 1215 - 1232 (2007/10/02)
The enantiomerically pure glycine derivatives (R)- and (S)-Boc-BMI, commercially available on a kg scale, are used as starting materials (Scheme 1) for the preparation of (i) open-chain amino acids such as α-deuterio amino acids (4,5), β-arylalanines (2), aspartic acid derivatives (6, 7a, 8), or ω-halo amino acids (7b,c, 12, 13, 16, 17, 19, 22), (ii) of α-aminocycloalkanecarboxylic acids (9, 11), and (iii) of heterocyclic α-amino acids (14, 15, 18, 20) containing azetidine, pyrrolidine, piperidine or perhydroazepine rings.Inversion by deprotonation/protonation ordeuteration allows to prepare either enantiomer of an amino acid from the same Boc-BMI enantiomer (Scheme 5).Effects of additives such as the cyclic urea DMPU, lithium salts, or secondeary amines upon the reactivity of lithium enolates are discussed and, in part, exploited.
Side chain conformations of oxytoxin and vasopressin studied by NMR observation of isotopic isomers
Cowburn,Live,Fischman,Agosta
, p. 7435 - 7442 (2007/10/02)
The side chain conformations of several residues of oxytocin and left bracket 8-arginine right bracket vasopressin are compared by using measurements of the circumjacent vicinal couplings of **1H** alpha , **1**3C prime , and **1**5N prime to beta protons
