691410-75-0

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 3901-07-3 3-(4-methoxy-phenyl)acrylic acid methyl ester 
• 851136-39-5 (R)-N-[2-hydroxy-1-(4-methoxyphenyl)ethyl]benzamide 
• 851136-42-0 (4R,5R)-2-phenyl-4-(4-methoxyphenyl)-1,3-oxazoline-5-carbonitrile 
• 851136-37-3 (R)-N-(1-(4-methoxyphenyl)-2-oxoethyl)benzamide 
• 714951-38-9 tert-butyl (R,R,R)-2-hydroxy-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-(4'-methoxyphenyl)propanoate 
• 714951-39-0 tert-butyl (2R,3R)-3-amino-2-hydroxy-3-(4-methoxyphenyl)propanoate 
• 53484-52-9 tert-butyl (E)-3-(4-methoxyphenyl)prop-2-enoate 
• 714951-40-3 tert-butyl (4R,5R)-4-(4-methoxyphenyl)-2-oxo-1,3-oxazolidine-5-carboxylate 
• 503-38-8 trichloromethyl chloroformate 
• 691410-80-7 (2S,3R)-3-Acetylamino-2-methanesulfonyloxy-3-(4-methoxy-phenyl)-propionic acid methyl ester 
• 691410-73-8 (2S,3R)-3-Acetylamino-2-hydroxy-3-(4-methoxy-phenyl)-propionic acid methyl ester 
• 691410-72-7 (4R,5R)-4-(4-Methoxy-phenyl)-2-methyl-4,5-dihydro-oxazole-5-carboxylic acid methyl ester 
• 851136-40-8 (2R,3R)-2-hydroxy-3-(4-methoxyphenyl)-3-N-benzoylaminopropionitrile 

Downstream Products

• 220736-25-4 (4R,5R)-cytoxazone 
• 691410-76-1 methyl (4R,5R)-4-(4-methoxyphenyl)-1,3-oxazolidine-2-one-5-carboxylate 

Relevant academic research and scientific papers

Stereoselective synthesis of (?)-cytoxazone and its unnatural congener (+)-5-epi-cytoxazone

An interesting protocol for stereoselective synthesis of (?)-cytoxazone and its unnatural stereoisomer (+)-5-epi-cytoxazone from d-4-hydroxyphenylglycine in overall yields of 10% and 16%, respectively, is described. The stereoselective addition of cyanide

Synthesis of (-)-cytoxazone and (+)-epi-cytoxazone: The chiral pool approach

Immunomodulator (-)-cytoxazone and its epimer (+)-epi-cytoxazone were synthesized starting from (D)-(-)-4-hydroxyphenylglycine. Homologation of the amino acid was achieved via the corresponding aldehyde, by a cyanohydrin reaction. The racemization of high

Asymmetric synthesis of (4R,5R)-cytoxazone and (4R,5S)-epi-cytoxazone.

(4R,5R)-Cytoxazone has been prepared in four steps and in 61% overall yield and >98% ee. Conjugate addition of lithium (R)-N-benzyl-N-[small alpha]-methylbenzylamide to tert-butyl (E)-3-(p-methoxyphenyl)prop-2-enoate and subsequent in situ diastereoselect

Stereoselective synthesis of (-)-cytoxazone and (+)-epi-cytoxazone

Optically pure (-)-cytoxazone was synthesized, starting from methyl p-methoxycinnamate, in six steps and in 31% overall yield. The required anti-aminoalcohol configuration was established by combining Sharpless asymmetric aminohydroxylation with the confi