69181-53-9Relevant academic research and scientific papers
INDOLE-BASED COMPOUNDS
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Paragraph 0954-0958, (2021/12/03)
The present invention relates to a compound of formula (I) or a stereoisomer, enantiomer, racemic, or tautomer thereof, formula (I) wherein r, R1, R2, R3, R4, R5, R6 and L1 have
Synthesis, Antiproliferative Effect, and Topoisomerase II Inhibitory Activity of 3-Methyl-2-phenyl-1 H-indoles
Argaez, Aida Nelly Garcia,Dalla Via, Lisa,Hyeraci, Mariafrancesca,Kikelj, Danijel,Ma?i?, Lucija Peterlin,Passarella, Daniele,Secci, Daniela,Toma?i?, Tihomir,Zidar, Nace
, p. 691 - 697 (2020/07/14)
A series of 3-methyl-2-phenyl-1H-indoles was prepared and investigated for antiproliferative activity on three human tumor cell lines, HeLa, A2780, and MSTO-211H, and some structure-activity relationships were drawn up. The GI50 values of the most potent compounds (32 and 33) were lower than 5 μM in all tested cell lines. For the most biologically relevant derivatives, the effect on human DNA topoisomerase II relaxation activity was investigated, which highlighted the good correlation between the antiproliferative effect and topoisomerase II inhibition. The most potent derivative, 32, was shown to induce the apoptosis pathway. The obtained results highlight 3-methyl-2-phenyl-1H-indole as a promising scaffold for further optimization of compounds with potent antiproliferative and antitopoisomerase II activities.
1--3-substituted-amino-propan-2-ols/propanes as Potential Biodynamic Agents
Kumar, Surat,Rastogi, Shri Nivas
, p. 659 - 663 (2007/10/02)
1-Aryloxy-2,3-epoxypropanes (5-7), obtained by the alkylation of phenols (1-3) with epichlorohydrin, on condensation with appropriate amines furnish the desired 1-furanyloxy- and p-(cyclopentenylindolyl)phenoxy>-3-substituted-amino-propan-2-ols (
