6921-44-4

Usage

Uses

Since no specific uses have been reported for Benzene, 1-cyclopropyl-4-nitro-, its applications can be inferred based on its chemical structure and properties. It is likely used as a building block in the synthesis of more complex molecules in chemical research or industry.
Used in Chemical Research:
Benzene, 1-cyclopropyl-4-nitrois used as a synthetic intermediate for the creation of more complex molecules, facilitating advancements in chemical research.
Used in Industrial Applications:
Benzene, 1-cyclopropyl-4-nitrois used as a chemical building block in the production of various industrial products, leveraging its reactivity and properties.

InChI:InChI=1/C9H9NO2/c11-10(12)9-5-3-8(4-6-9)7-1-2-7/h3-7H,1-2H2

Upstream product

• 873-49-4 cyclopropylbenzene 
• 100-13-0 4-nitrostyrene 
• 1774-47-6 trimethylsulfoxonium iodide 
• 57807-27-9 (4-iodophenyl)cyclopropane 
• 100-00-5 4-chlorobenzonitrile 
• 411235-57-9 cyclopropylboronic acid 
• 23348-99-4 1-(4-nitrophenyl)cyclopropane-1-carboxylic acid 
• 408328-42-7 1-(4-nitrophenyl)-1-cyclopropylcarbonitrile 
• 555-21-5 4-Nitrophenylacetonitrile 
• 925430-09-7 tricyclopropylbismuthane 
• 636-98-6 p-nitrobenzene iodide 
• 201230-82-2 carbon monoxide 
• 1065010-87-8 potassium cyclopropyltrifluoroborate 
• 586-78-7 para-nitrophenyl bromide 

Downstream Products

• 49678-08-2 3-(4-nitrophenyl)-propenal 
• 1466-88-2 2-nitrocinnamic aldehyde 
• 90712-51-9 5-(2-nitrophenyl)isoxazoline 
• 90712-50-8 5-(4-nitrophenyl)isoxazoline 
• 134920-41-5 N-[1-(4-Nitro-phenyl)-propyl]-acetamide 
• 97522-08-2 methyl α-methyl-5-cyclopropyl-2-nitrobenzeneacetate 
• 3158-71-2 4-cyclopropylaniline 
• 10342-59-3 1-nitro-4-propyl-benzene 
• 2696-84-6 4-propylaniline 
• 10557-11-6 4,4'-Dicyclopropyl-biphenyl 
• 19936-09-5 2-(4-cyclopropylphenyl)-2-propanol 
• 1798-82-9 4-cyclopropylbenzoic acid 
• 1124-14-7 1-bromo-4-cyclopropylbenzene 
• 30546-33-9 1-(4-nitro-2-nitroso-phenyl)-propan-1-one 

Relevant academic research and scientific papers

IMIDAZOPYRIDINE DERIVATIVE COMPOUNDS AND USE OF SAME

One aspect of the present invention provides a compound selected from among a compound of chemical formula 1 having lysine-specific demethylase-1 (LSD1) inhibitory activity, and a tautomer, a stereoisomer, and a solvate thereof, and pharmaceutically accep

Preparation method of cycloalkane compound

The invention provides a preparation method of a cycloalkane compound, and concretely provides a new cycloalkane construction method for preparing a compound represented by formula I. The preparationmethod is green and environment-friendly.

PYRAZOLE DERIVATIVE COMPOUND AND USE THEREOF

Provided is a compound represented by Formula 1 having an inhibitory activity on lysine-specific demethylase-1 (LSD1), an optical isomer, a solvate, a tautomer, or a pharmaceutically acceptable salt thereof, which is effective in preventing or treating a

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Palladium-Catalyzed Carbonylative Cross-Coupling Reaction between Aryl(Heteroaryl) Iodides and Tricyclopropylbismuth: Expedient Access to Aryl Cyclopropylketones

The carbonylative cross-coupling reaction between aryl and heteroaryl iodides and tricyclopropylbismuth is reported. The reaction is catalyzed by (SIPr)Pd(allyl)Cl, a NHC-palladium(II) catalyst, operates under 1 atm of carbon monoxide and tolerates a wide range of functional groups. The use of lithium chloride was found to provide higher yields of the desired aryl cyclopropylketones. The conditions were also applied to the carbonylative cross-coupling of an iodoalkene to afford the corresponding alkenyl cyclopropylketone.

NOVEL PRECATALYST SCAFFOLDS FOR CROSS-COUPLING REACTIONS, AND METHODS OF MAKING AND USING SAME

The present invention provides novel transition-metal precatalysts that are useful in preparing active coupling catalysts. In certain embodiments, the precatalysts of the invention are air-stable and moisture-stable. The present invention further provides methods of making and using the precatalysts of the invention.

Metal Nanoparticles Catalyzed Selective Carbon-Carbon Bond Activation in the Liquid Phase

Understanding the C-C bond activation mechanism is essential for developing the selective production of hydrocarbons in the petroleum industry and for selective polymer decomposition. In this work, ring-opening reactions of cyclopropane derivatives under hydrogen catalyzed by metal nanoparticles (NPs) in the liquid phase were studied. 40-atom rhodium (Rh) NPs, encapsulated by dendrimer molecules and supported in mesoporous silica, catalyzed the ring opening of cyclopropylbenzene at room temperature under hydrogen in benzene, and the turnover frequency (TOF) was higher than other metals or the Rh homogeneous catalyst counterparts. Comparison of reactants with various substitution groups showed that electron donation on the three-membered ring boosted the TOF of ring opening. The linear products formed with 100% selectivity for ring opening of all reactants catalyzed by the Rh NP. Surface Rh(0) acted as the active site in the NP. The capping agent played an important role in the ring-opening reaction kinetics. Larger particle size tended to show higher TOF and smaller reaction activation energy for Rh NPs encapsulated in either dendrimer or poly(vinylpyrrolidone). The generation/size of dendrimer and surface group also affected the reaction rate and activation energy.

Design of a versatile and improved precatalyst scaffold for palladium-catalyzed cross-coupling: (η3-1-tBu-indenyl)2(μ-Cl)2Pd2

We describe the development of (η3-1-tBu-indenyl)2(μ-Cl)2Pd2, a versatile precatalyst scaffold for Pd-catalyzed cross-coupling. Our new system is more active than commercially available (η3-cinnamyl)2(μ-Cl)2Pd2 and is compatible with a range of NHC and phosphine ligands. Precatalysts of the type (η3-1-tBu-indenyl)Pd(Cl)(L) can either be isolated through the reaction of (η3-1-tBu-indenyl)2(μ-Cl)2Pd2 with the appropriate ligand or generated in situ, which offers advantages for ligand screening. We show that the (η3-1-tBu-indenyl)2(μ-Cl)2Pd2 scaffold generates highly active systems for a number of challenging cross-coupling reactions. The reason for the improved catalytic activity of systems generated from the (η3-1-tBu-indenyl)2(μ-Cl)2Pd2 scaffold compared to (η3-cinnamyl)2(μ-Cl)2Pd2 is that inactive PdI dimers are not formed during catalysis.

Stereospecific Pd-catalyzed cross-coupling reactions of secondary alkylboron nucleophiles and aryl chlorides

We report the development of a Pd-catalyzed process for the stereospecific cross-coupling of unactivated secondary alkylboron nucleophiles and aryl chlorides. This process tolerates the use of secondary alkylboronic acids and secondary alkyltrifluoroborates and occurs without significant isomerization of the alkyl nucelophile. Optically active secondary alkyltrifluoroborate reagents undergo cross-coupling reactions with stereospecific inversion of configuration using this method.