69231-11-4

Upstream product

• 3182-95-4 L-Phenylalaninol 
• 2258-42-6 formyl acetic anhydride 
• 63-91-2 L-phenylalanine 
• 64-18-6 formic acid 
• 3182-95-4 L-phenylalaninol 

Downstream Products

• 104876-32-6 L-(-)-2-isocyano-3-phenylpropyl formate 
• 1197-33-7 2-methyl-3-phenyl-acrylonitrile 
• 104876-36-0 L-(+)-2-cyano-3-phenylpropyl formate 
• 123542-78-9 (S)-2-<<(S)-2-(6-Methoxy-2-naphthyl)propionylamino>methyl>-3-phenylpropionsaeure-methylester 
• 123542-75-6 (R)-2-Benzyl-3-chlorpropionohydroxamsaeure-benzylester 
• 123542-76-7 (S)-3-Benzyl-1-(benzyloxy)-2-azetidinon 
• 123565-85-5 (R)-2-Benzyl-3-(formyloxy)propionitril 
• 123565-86-6 (S)-3-Benzyl-1-hydroxy-2-azetidinon 
• 123542-74-5 (R)-2-chloromethylbenzenepropanoic acid 
• 123761-13-7 (S)-β²hPhe-OMe 
• 123542-72-3 (S)-2-benzyl-3-hydroxypropanoic acid methyl ester 
• 123542-73-4 (R)-2-Benzyl-3-chlorpropionsaeure-methylester 
• 123542-77-8 (S)-3-Benzyl-2-azetidinon 
• 123542-71-2 <(S)-2-Isocyan-3-phenylpropyl>formiat 

Relevant academic research and scientific papers

A New Approach to Enantiomerically Pure β-Lactams from α-Amino Acids by Applying the Isonitrile-Nitrile Rearrangement

(S)-Phenylalanine (1) was converted into (S)-3-benzyl-2-azetidinone (8b) by a multistep reaction sequence.The key step of this approach is a stereospecific isonitrile-nitrile rearrangement ( 3 -> 4) by flash pyrolysis, which may be performed in 20-g batch

The Synthetic Potential of the Isocyanide-Cyanide Rearrangement

Excellent chemical and optical yields (>96percent retention) of cyanides are achieved by vapor phase thermolysis or short contact flow thermolysis of isocyanides. trans-2-Butenyl isocyanide rearranges without concomitant allylic isomerization to trans-2-butenyl cyanide.Optically active 1-(formyloxymethyl)-2-phenylethyl cyanide is obtained from optically active L-phenylalanine as a new type of chiral pool synthon.