79848-03-6

Upstream product

• 98-88-4 benzoyl chloride 
• 87792-02-7 9-[3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-1-β-D-arabinofuranosyl]adenine 
• 69304-37-6 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 
• 79896-97-2 N6-benzoyl-9-β-D-arabinofuranosyladenine 
• 58-61-7 adenosine 
• 5536-17-4 arabinosyl adenine 
• 93-97-0 benzoic acid anhydride 
• 69304-45-6 3',5'-O-(1,1,3,3-tetra-isopropyldisiloxane-1,3-diyl)adenosine 

Downstream Products

• 1541908-40-0 N⁶-benzoyl-2′-O-levulinyl-3′,5′-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-adenosine-9-β-D-arabinofuranoside 
• 136904-70-6 2'-S-<9-(4-methoxyphenyl)xanthen-9-yl>-2'-thioadenosine 
• 136904-69-3 2'-Thioadenosine 
• 136904-73-9 2'deoxy-2'-<9-(4-methoxyphenyl)xanthen-9-yldithio>adenosine 
• 875112-51-9 N⁶-benzoyl-2'-(butyldithio)-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)adenosine 
• 875112-49-5 N⁶-benzoyl-2'-S-(4-methoxybenzyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-2'-thioadenosine 
• 875112-50-8 N⁶-benzoyl-2'-(butyldithio)-2'-deoxy-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)adenosine 
• 136923-03-0 6-N-benzoyl-9-<3,5-O-(1,1,3,3-tetra-isopropyldisiloxane-1,3-diyl)-2-O-trifluoromethanesulfonyl-β-D-arabinofuranosyl>adenine 

Relevant academic research and scientific papers

S-ANTIGEN TRANSPORT INHIBITING OLIGONUCLEOTIDE POLYMERS AND METHODS

Various embodiments provide STOPS? polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS? modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS? modified oligonucleotides, as determined by HBsAg Secretion Assay, is an EC50 that is less than 100 nM.

SYNTHESIS OF ARA-2'-O-METHYL-NUCLEOSIDES, CORRESPONDING PHOSPHORAMIDITES AND OLIGONUCLEOTIDES INCORPORATING NOVEL MODIFICATIONS FOR BIOLOGICAL APPLICATION IN THERAPEUTICS, DIAGNOSTICS, G- TETRAD FORMING OLIGONUCLEOTIDES AND APTAMERS

The present invention relates to synthesis, purification and methods to obtain high purity novel 2'-arabino-O-methyl nucleosides and the corresponding phosphoramidites of various arabinonucleoside bases and introduction of such units into defined sequence

Ribo-, Xylo-, and Arabino-configured adenine-based nucleoside phosphonates: Synthesis of monomers for solid-phase oligonucleotide assembly

Adenine-based, regioisomeric nucleoside phosphonates with ribo, xylo and arabino configuration were synthesized in the protected form suitable for the phosphotriester-like, solid-phase synthesis of oligonucleotides. Phosphonate moiety was protected by 4-m

Synthesis of 2'-thioadenosine

Reaction between 5-N-benzoyl-9-adenine (12a), prepared from 9-(β-D-arabinofuranosyl)adenine, and 9-(4-methoxyphenyl)xanthene-9-thiol (AXT, 7b) in the pr