136904-69-3 Usage
Uses
Used in Pharmaceutical Industry:
2'-THIOADENOSINE is used as a synthetic intermediate for the development of potent and selective inhibitors targeting erbB-1 (epidermal growth factor receptor) and erbB-2 (neu/her2 growth factor receptor) tyrosine kinases. These receptors play a crucial role in cell proliferation and differentiation, and their dysregulation has been associated with various cancers. By inhibiting these receptors, 2'-THIOADENOSINE-based compounds can potentially suppress tumor growth and progression, offering a new avenue for cancer treatment.
Additionally, 2'-THIOADENOSINE can be utilized in the development of novel drug delivery systems to improve the bioavailability and therapeutic outcomes of erbB-1 and erbB-2 inhibitors. This may involve the use of various organic and metallic nanoparticles as carriers for the efficient delivery of 2'-THIOADENOSINE-based compounds to cancer cells, enhancing their efficacy and reducing potential side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 136904-69-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,6,9,0 and 4 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 136904-69:
(8*1)+(7*3)+(6*6)+(5*9)+(4*0)+(3*4)+(2*6)+(1*9)=143
143 % 10 = 3
So 136904-69-3 is a valid CAS Registry Number.
136904-69-3Relevant academic research and scientific papers
Marriott, Jonathan H.,Mottahedeh, Mina,Reese, Colin B.
, p. 257 - 269 (1991)
Reaction between 5-N-benzoyl-9-adenine (12a), prepared from 9-(β-D-arabinofuranosyl)adenine, and 9-(4-methoxyphenyl)xanthene-9-thiol (AXT, 7b) in the pr
