69305-42-6

Basic information

• Product Name: 2,4,5-trimethyl-1-acetoxybenzene
• Synonyms: 2,4,5-trimethyl-1-acetoxybenzene
• CAS NO: 69305-42-6
• Molecular Weight: 178.231
• Mol File: 69305-42-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,4,5-trimethyl-1-acetoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-trimethyl-1-acetoxybenzene(69305-42-6)
• EPA Substance Registry System: 2,4,5-trimethyl-1-acetoxybenzene(69305-42-6)

Safety Data

• Hazardous Substances Data: 69305-42-6(Hazardous Substances Data)

Upstream product

• 79-21-0 peracetic acid 
• 496-78-6 2,4,5-trimethylphenol 
• 95-63-6 1,2,4-Trimethylbenzene 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 

Downstream Products

• 36436-65-4 2-acetyl-4,5-dimethylphenol 
• 58972-39-7 1-(2-hydroxy-3,4,5-trimethyl-phenyl)-ethanone 
• 527-35-5 2,3,5,6-tetramethylphenol 

Relevant articles and documents

Direct Acetoxylation of Arenes

Acetoxylation of arenes is an important reaction and an unmet need in chemistry. We report a metal-free, direct acetoxylation reaction using sodium nitrate under an anhydrous environment of trifluoroacetic acid, acetic acid, and acetic anhydride. Arenes (31 examples), with oxidation potentials (Eox, in V vs SCE) lower than benzene (2.48 V), were acetoxylated with good yields and regioselectivity. A stepwise, single electron-transfer mechanism is proposed.

REACTION OF 1,2,4-TRIMETHYLBENZENE WITH PERACETIC ACID

The oxidation of 1,2,4-trimethylbenzene with peracetic acid leads to the formation of trimethylphenols and hydroquinones, which undergo transformations to the corresponding benzoquinones and products from oxidative cleavage of the ring.The controlling stage of the process is the electrophilic hydroxylation of 1,2,4-trimethylbenzene.