6932-93-0

Upstream product

• 3847-19-6 2-acetoxypyridine 
• 613-48-9 N,N-diethyl-p-toluidine 
• 135273-33-5 4-methyl-N-ethyl-N-benzylaniline 
• 108-24-7 acetic anhydride 
• 35113-87-2 N-ethyl-N-methyl-4-methylaniline 
• 64-67-5 diethyl sulfate 
• 103-89-9 4-Methylacetanilide 
• 99-99-0 1-methyl-4-nitrobenzene 
• 557-20-0 diethylzinc 
• 75-36-5 acetyl chloride 
• 624-31-7 4-tolyl iodide 
• 625-50-3 N-ethylacetamide 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 143085-04-5 N-tert-Butyl-2-(ethyl-p-tolyl-amino)-2-phenyl-acetamide 

Downstream Products

• 37637-58-4 ethyl-(4-methyl-2-nitrophenyl)amine 

Relevant academic research and scientific papers

Room Temperature Cu-Catalyzed N-Arylation of Oxazolidinones and Amides with (Hetero)Aryl Iodides

N,N′-Bis(pyridin-2-ylmethyl)oxalamide (BPMO) was found to be an apposite promoter for the Cu-catalyzed N-arylation of oxazolidinones and primary and secondary amides with (hetero)aryl iodides at room temperature. Excellent chemoselectivity reached between

Electrophilic Amination with Nitroarenes

An exceptionally general electrophilic amination, which directly transforms commercially available nitroarenes into alkylated aromatic aminoboranes with zinc organyl compounds was developed. The reaction starts with a two-step partial reduction of the nitro group to a nitrenoid, which is used in situ as the electrophilic amination reagent. To facilitate isolation, the resulting air- and moisture-sensitive aminoboranes were reacted with a range of electrophiles. The method not only represents a direct transformation of nitro compounds into electrophilic amination reagents but also provides an elegant alternative to dehydrocoupling methods for the generation of aminoboranes.

Free radical cyclization reactions of alkylsulfonyl and alkylthio substituted aromatic amide derivatives

Free radical cyclization reactions of alkylsulfonyl and alkylthio substituted aromatic amide derivatives are described. Carbon radicals can be generated efficiently from the sulfonyl radical induced reaction of allylsulfones or the oxidation of carbonyl c

A new phase transfer catalyst (PTC) for N-alkylation reactions

Hexamethylene tetramine bromide HMTA+ Br- - a new phase transfer catalyst is reported for N-Alkylation reactions of industrially important anilides.

Oxidative Dealkylation of 4-Substituted N,N-Dialkylanilines with Molecular Oxygen in the Presence of Acetic Anhydride Promoted by Cobalt(II) or Copper(I) Chloride

The reaction of 4-substituted N,N-dimethylanilines 1a-d with acetic anhydride 5 proceeded efficiently in the presence of a catalytic amount of cobalt(II) or copper(I) chloride under oxygen to give the corresponding N-methylacetanilides 2a-d along with N-methylformanilides 3a-d.The reaction of N-alkyl-N-methyl-p-toluidines 1f-h with cobalt chloride revealed that the order of reactivity of the N-substituents follows the sequence allyl > benzyl >/= methyl > ethyl, while in the case of copper chloride the order was benzyl > allyl > methyl > ethyl.Aldehydes 18a-e and phenylglyoxylic acid derivatives 18f and 18g were obtained in fair to good yield from the reaction of n-substituted N-ethyl-p-toluidines 17a-g.

Cobalt(II) Chloride Catalyzed Oxidation of 4-Substituted N,N-Dialkylanilines with Molecular Oxygen in the Presence of Acetic Anhydride

The oxidation of 4-substituted N,N-dialkylanilines with molecular oxygen using a catalytic amount of cobalt(II) chloride efficiently proceeds in the presence of acetic anhydride to give N-alkylacetanilides in good yields along with N-alkylformanilides.

AN ANOMALOUS DEALKYLATION-ACYLATION OF N,N-DIALKYLANILINES

N,N-Dialkylaniline undergoes a thermal N-dealkylation and acylation in the presence of 2-acetoxypyridines.