69352-22-3Relevant academic research and scientific papers
Small peptide diversification through photoredox-catalyzed oxidative C-terminal modification
Le Du, Eliott,Garreau, Marion,Waser, Jér?me
, p. 2467 - 2473 (2021)
A photoredox-catalyzed oxidative decarboxylative coupling of small peptides is reported, giving access to a variety ofN,O-acetals. They were used as intermediates for the addition of phenols and indoles, leading to novel peptide scaffolds and bioconjugates. Amino acids with nucleophilic side chains, such as serine, threonine, tyrosine and tryptophan, could also be used as partners to access tri- and tetrapeptide derivatives with non-natural cross-linking.
