6937-62-8Relevant academic research and scientific papers
C-H amination of purine derivatives via radical oxidative coupling
Luo, Zheng,Jiang, Ziyang,Jiang, Wei,Lin, Dongen
, p. 3710 - 3718 (2018/04/14)
An oxidative coupling reaction between purines and alkyl ethers/benzyl compounds was developed to synthesize a series of N9 alkylated purine derivatives using n-Bu4NI as a catalyst and t-BuOOH as an oxidant. This protocol uses commercially available, inexpensive catalysts and oxidants and has a wide range of substrates with a simple operation.
8-Bromination of 2,6,9-trisubstituted purines with pyridinium tribromide
Bliman, David,Pettersson, Mariell,Bood, Mattias,Gr?tli, Morten
, p. 2929 - 2931 (2014/05/06)
2,6,9-Trisubstituted purines are brominated in high yields using pyridinium tribromide as the brominating reagent. This procedure works excellently for electron-rich purines having electron-donating substituents at the 2- and 6-positions. The use of pyridinium tribromide, a crystalline alternative to elemental bromine, improves the bromination procedure for this type of substrate as the reagent is easy to handle and the work-up and purification procedures are simplified.
Intramolecular glycosylation as a regio- and stereocontrolled approach for the synthesis of 8-oxo-purine nucleosides
Sugimura, Hideyuki,Nitta, Daisuke
scheme or table, p. 4460 - 4463 (2012/09/25)
Intramolecular glycosylation of purine derivatives that are temporarily connected to the 5 position of ribofuranosyl donors at their 8 position through an ethereal linkage leads to 8-oxo-purine β-nucleosides in a stereoselective manner.
