69390-41-6Relevant articles and documents
Practical syntheses of N-acetyl (E)-β-arylenamides
Cai, Zhihua,Liu, Guodu,Jiao, Guangjun,Senanayake, Chris H.,Tang, Wenjun
, p. 3355 - 3360 (2014/01/06)
A facile and practical method for the preparation of (E)-β- arylenamides [(E)-N-(1-arylprop-1-en-2-yl]acetamides] has been developed by reductive acetylation of the corresponding oximes with iron(II) acetate as the reducing reagent. Employment of hexamethylphosphoramide as the solvent was found to be critical for the high E/Z selectivity. The methodology has been applied in efficient syntheses of a key chiral intermediate of tamsulosin by asymmetric hydrogenation. Georg Thieme Verlag Stuttgart . New York.
Enantioselective hydrogenation of (Z)- and (E)-β-arylenamides catalyzed by rhodium complexes of monodentate chiral spiro phosphorous ligands: A new access to chiral β-arylisopropylamines
Zhu, Shou-Fei,Liu, Tao,Yang, Shuang,Song, Song,Zhou, Qi-Lin
supporting information; experimental part, p. 7685 - 7690 (2012/09/07)
A highly enantioselective rhodium-catalyzed hydrogenation of both (Z)- and (E)-β-arylenamides was developed by using monodentate chiral spiro phosphite and phosphine ligands, respectively. The hydrogenation reaction provides an efficient access to optically active β-arylisopropylamines, important building blocks for the synthesis of biologically active compounds.
A new selective reduction of nitroalkenes into enamides
Laso, Nieves M.,Quiclet-Sire, Beatrice,Zard, Samir Z.
, p. 1605 - 1608 (2007/10/03)
Conjugated nitroalkenes can be reduced into enamides by a combination of iron powder, a carboxylic acid, and the corresponding anhydride.