6940-45-0

Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-6-hydroxy-5-(beta-hydroxyethyl)-4-methylpyrimidine is used as an intermediate compound for the synthesis of thiamine (vitamin B1), which is essential for the proper functioning of the brain, heart, and nervous system. Its presence in the biosynthesis process highlights its importance in maintaining overall health and well-being.
Used in Nutritional Supplements:
2-AMINO-6-HYDROXY-5-(B-HYDROXYETHYL)-4-METHYLPYRIMIDINE is used as a precursor in the formulation of nutritional supplements that aim to provide the necessary amounts of thiamine to individuals who may have deficiencies or require additional support for their metabolic processes. The supplementation of thiamine can help improve energy production and support the overall health of various bodily systems.
Used in Research and Development:
2-Amino-6-hydroxy-5-(beta-hydroxyethyl)-4-methylpyrimidine is utilized in research settings to study the biosynthesis of thiamine and its role in various biological processes. This knowledge can be applied to develop new therapeutic strategies and understand the underlying mechanisms of thiamine-related deficiencies and their impact on human health.

InChI:InChI=1/C7H11N3O2/c1-4-5(2-3-11)6(12)10-7(8)9-4/h11H,2-3H2,1H3,(H3,8,9,10,12)

Upstream product

• 593-85-1 guanidine carbonate 
• 517-23-7 3-acetyl-2-oxo-4,5-dihydrofuran 
• 124-46-9 guanidine hydrogen carbonate 
• 50-01-1 guanidine hydrochloride 
• 113-00-8 guanidine nitrate 

Downstream Products

• 306314-93-2 4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine 
• 306314-92-1 2-amino-4-methyl-7-(N-benzyl)pyrrolo[2,3-d]pyrimidine 
• 306314-91-0 2-amino-4-methyl-7-(N-benzyl)piperidinyl[2,3-d]pyrimidine 
• 306315-03-7 N-(7-benzyl-5-ethynyl-4-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropanamide 
• 306315-00-4 2,2-dipivaloylamino-4-methyl-7-(N-benzyl)pyrrolo[2,3-d]pyrimidine 
• 306315-01-5 2,2-dipivaloylamino-4-methyl-5-iodo-7-(N-benzyl)pyrrolo[2,3-d]pyrimidine 
• 306315-02-6 2,2-dipivaloylamino-4-methyl-5-trimethylethynyl-7-(N-benzyl)pyrrolo[2,3-d]pyrimidine 
• 306314-88-5 AAG₁₁₃-161 
• 306314-99-8 diethyl N-{2-pivaloylamino-4-methyl[(pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamate 
• 306314-98-7 diethyl N-{2-pivaloylamino-4-methyl[(pyrrolo[2,3-d]pyrimidin-5-yl)ethynyl]benzoyl}-L-glutamate 
• 306315-04-8 diethyl N-{2-pivaloylamino-4-methyl[(pyrrolo[2,3-d]pyrimidin-5-yl)ethynyl-7-(N-benzyl)]benzoyl}-L-glutamate 
• 306315-05-9 diethyl N-{2-pivaloylamino-4-methyl[(pyrrolo[2,3-d]pyrimidin-5-yl)ethyl-7-(N-benzyl)]benzoyl}-L-glutamate 
• 942139-45-9 C₃₁H₄₇N₇O₆ 
• 78831-62-6 2-amino-5-(2-bromoethyl)-6-methylpyrimidin-4-(3H)one 

Relevant academic research and scientific papers

Direct synthesis of 5- and 6-substituted 2-aminopyrimidines as potential non-natural nucleobase analogues

A series of 2-aminopyrimidine derivatives, substituted at 5- and 6-positions, were synthesized. The reaction was carried out in a single step by treatment of the corresponding β-ketoester or β-aldehydoester with guanidine hydrochloride in the presence of K2CO3, in a microwave-assisted method without the requirement of solvent. A unique 1:1 co-crystal structure was obtained which shows that a 6-phenyl-2- aminopyrimidinone forms a strong nucleobase-pair with cytosine, involving three hydrogen bonds. The base-pair was found to be as strong as that of natural guanine:cytosine (G:C), signifying the potential application of the synthesized derivatives. Additionally, we also report a second co-crystal involving 5-isopropyl-6-methyl-2-aminopyrimidinone and cytosine in a 1:1 ratio, which also shows strong base-pairing properties. the Partner Organisations 2014.

Fluorinated supramolecular polymers

The present invention relates to a fluorinated supramolecular polymer containing at least 5% by weight of covalently bonded fluorine atoms, based on the total weight of the fluorinated supramolecular polymer, said fluorinated supramolecular polymer comprising a fluorinated polymer chain and a (self-)complementary unit capable of forming at least three hydrogen bonds, said (self-)complementary unit being covalently bonded to said fluorinated polymer chain. The present invention also relates fluorinated supramolecular material comprising (a) a fluorinated supramolecular polymer and (c) a non-fluorinated polymer and/or (d) a fluorinated compound, the non-fluorinated polymer being a polymer containing less than 5% by weight of covalently bonded fluorine atoms, based on the total weight of the non-fluorinated polymer, and the fluorinated compound being either a low molecular weight fluorinated compound comprising at least one fluorine atom and having a molecular weight of 34.(molecular weight of CH3F) to 600 atomic mass units (amu), or a fluoropolymer containing at least 5% by weight of covalently bonded fluorine atoms, based on the total weight of the fluoropolymer and having a Mn from about 600 to about 5000.

HIGH FLOW SUPRAMOLECULAR COMPOUNDS

The present invention relates to a supramolecular compound comprising a low molecular weight, apolar compound, said low molecular weight, apolar compound having a melting point of below 45°C, a molecular weight of about 80 to about 1500 amu and a HLB-valueof lower than 8, said low molecular weight, apolar compound bearing a single 4H-unit per molecule. The supramolecular compound according to the present invention may be used in coating, ink, toner, resin, lacquer, adhesive or glue compositions.

Design, synthesis, and x-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent

A novel N-{2-amino-4-methyl[(pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl}-L-glutamic acid (3a) was designed and synthesized as a potent dual inhibitor of thymidylate synthase (TS) and dihydrofolate reductase (DHFR) and as an antitumor agent. Compound 3b, t