69407-71-2Relevant academic research and scientific papers
2-Oxo-1,8-naphthyridine-3-carboxylic Acid Derivatives with Potent Gastric Antisecretory Properties
Santilli, Arthur A.,Scotese, Anthony C.,Bauer, Raymond F.,Bell, Stanley C.
, p. 2270 - 2277 (2007/10/02)
The syntheses of 2-oxo-1,8-naphthyridine-3-carboxylic acid derivatives having potent gastric antisecretory properties in the pyloric-ligated (Shay) rat model are described.Two of the more potent compounds tested that were selected for more detailed dose-r
The Chemistry of 3-Azaisatoic Anhydrides. Synthesis and Reactions of Polyaza Heterocycles
Coppola, Gary M.,Fraser, James D.,Hardtmann, Goetz E.,Shapiro, Michael J.
, p. 193 - 206 (2007/10/02)
The preparation of a variety of N-substituted 3-azaisotoic anhydrides 3 and 8 is described.These anhydrides reacted with thiopseudoureas to give interesting bicyclic, tricyclic, and tetracyclic heterocycles many of which are new ring systems.One such hete
4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives
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, (2008/06/13)
4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives are anti-secretory agents for use in the treatment of peptic ulcer disease.
Antisecretory 4-oxy-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives
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, (2008/06/13)
Substituted 4-oxy-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives as gastric antisecretory agents for use in the treatment of peptic ulcer disease.
4-Hydroxy-pyrido[2,3-b]pyridine-2(1H)-one-3-carboxylic acids and esters
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, (2008/06/13)
Anti-allergic 4-hydroxy-pyrido[2,3-b]pyridine-2(1H)-one-3-carboxylic acids and esters are prepared by reacting a 3,4-dihydro-1,3-dioxo-1H-pyrido[2,3-d][1,3]oxazine (a 3-azaisatoic anhydride) with an alkali metal salt of a malonic ester.
