69422-72-6

Usage

Uses

Used in Agriculture:
2,4,6-Trichloronicotinic acid is used as a herbicide for controlling the growth of broadleaf weeds and invasive plant species. It is effective in disrupting the photosynthesis process in target plants, leading to their eventual death.
Used in Research and Laboratory Settings:
2,4,6-Trichloronicotinic acid is used as a building block in the synthesis of various pharmaceutical and agrochemical compounds. Its versatile chemical properties make it a valuable component in the development of new and innovative products in these industries.

InChI:InChI=1/C6H2Cl3NO2/c7-2-1-3(8)10-5(9)4(2)6(11)12/h1H,(H,11,12)

Upstream product

• 16063-69-7 2,4,6-trichloropyridine 
• 124-38-9 carbon dioxide 
• 2587-00-0 2,6-dichloropyridine N-oxide 
• 2402-78-0 2,6-dichloropyridine 

Downstream Products

• 69422-73-7 2,4,6-trichloronicotinoyl chloride 
• 1391001-28-7 tert-butyl 4-(4-(7-chloro-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-5-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 
• 1390655-18-1 8-(2,6-dichlorobenzyl)-6-(4-(piperazin-1-yl)phenylamino)-1,2,3,4-tetrahydropyrido[4,3-e][1,4]diazepin-5-one 
• 1390656-61-7 tert-butyl 4-(4-(8-chloro-5-oxo-2,3,4,5-tetrahydro-1H-pyrido[4,3-e][1,4]diazepin-6-ylamino)phenyl)piperazine-1-carboxylate 
• 1390655-15-8 8-(2,6-dichlorobenzyl)-6-{[4-(piperazin-1-yl)phenyl]amino}-1,2,3,4-tetrahydro-5H-pyrido[2,3-e][1,4]diazepin-5-one 
• 1390656-57-1 tert-butyl 4-(4-(8-chloro-5-oxo-2,3,4,5-tetrahydro-1H-pyrido[2,3-e][1,4]diazepin-6-ylamino)phenyl)piperazine-1-carboxylate 
• 1390655-14-7 8-(2,6-dichlorobenzyl)-6-{[2-methoxy-4-(piperazin-1-yl)phenyl]amino}-1,2,3,4-tetrahydro-5H-pyrido[2,3-e][1,4]diazepin-5-one 
• 1390656-56-0 tert-butyl 4-(4-(8-chloro-5-oxo-2,3,4,5-tetrahydro-1H-pyrido[2,3-e][1,4]diazepin-6-ylamino)-3-methoxyphenyl)piperazine-1-carboxylate 

Relevant academic research and scientific papers

BICYCLIC INHIBITORS OF ALK

The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, Formula (1) wherein R1, R2, R3, X, Y, Z, A, B, G1, m, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

BICYCLIC INHIBITORS OF ALK

The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, wherein R1, X, Y, Z, A, B, G1, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

BICYCLIC INHIBITORS OF ANAPHASTIC LYMPHOMA KINASE

Disclosed are compounds of formula (Ⅰ) and their pharmaceutical acceptable salts, wherein R1, R2, R3, X, Y, Z, A, B, G1, m and n are defined in the description. The compositions containing the said compounds used for inhibiting kinases such as anaphastic lymphoma kinase (ALK) and methods of treating diseases such as cancer are disclosed.

BICYCLIC INHIBITORS OF ALK

The present invention relates to compounds of formula (1) or pharmaceutical acceptable salts, Formula (1) wherein R1, R2, R3, X, Y, Z, A, B, G1, m, and n are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

Synthesis and Structure-Activity Relationships of Novel 7-Substituted 1,4-Dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acids as Antitumor Agents. Part 2

We have previously reported that a series of 7-substituted 6-fluoro-1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids possess moderate cytotoxic activity. In a further attempt to find clinically useful antitumor agents, we investigated the structure-activity relationships (SARs) of a new series of compounds obtained by changing the C-6 position of the fluorine atom in addition to the C-5 and C-7 positions and evaluating their cytotoxic activity against several murine and human tumor cell lines. Our results showed that the 6-unsubstituted 1,8-naphthyridine structure had the most potent cytotoxic activity against murine P388 leukemia twice that of the 6-fluoro analogue. In addition, introduction of an amino group at the C-5 position did not have any substantial effect on the cytotoxic activity, while both the 5-chloro and 5-trifluoromethyl groups decreased the cytotoxic activity by 5- to 10-fold. Moreover, aminopyrrolidine derivatives at the C-7 position showed more potent cytotoxic activity than other amines or carbon derivatives. Among the 7-(3-aminopyrrolidinyl) derivatives, the trans-3-methoxy-4-methylaminopyrrolidinyl derivative (271) was determined to have potent cytotoxic activity in both in vitro and in vivo assays and high water solubility. Finally, the (S,S)-isomer (AG-7352, 3) of 271, with a cytotoxic activity against human tumor cell lines more potent than that of etoposide, was selected for further development.

Compounds, processes for the preparation thereof and anti-tumor agents

This invention relates to pyridone-carboxylic acid derivatives of the following formula or salts thereof: STR1 wherein R1 is a hydrogen atom, a halogen atom, etc., R2 is a carboxyl group etc., R3 is a hydrogen atom etc., A