6943-47-1Relevant academic research and scientific papers
Promoting Frustrated Lewis Pairs for Heterogeneous Chemoselective Hydrogenation via the Tailored Pore Environment within Metal–Organic Frameworks
Niu, Zheng,Zhang, Weijie,Lan, Pui Ching,Aguila, Briana,Ma, Shengqian
supporting information, p. 7420 - 7424 (2019/04/27)
Frustrated Lewis pairs (FLPs) have recently been advanced as efficient metal-free catalysts for catalytic hydrogenation, but their performance in chemoselective hydrogenation, particularly in heterogeneous systems, has not yet been achieved. Herein, we demonstrate that, via tailoring the pore environment within metal–organic frameworks (MOFs), FLPs not only can be stabilized but also can develop interesting performance in the chemoselective hydrogenation of α,β-unsaturated organic compounds, which cannot be achieved with FLPs in a homogeneous system. Using hydrogen gas under moderate pressure, the FLP anchored within a MOF that features open metal sites and hydroxy groups on the pore walls can serve as a highly efficient heterogeneous catalyst to selectively reduce the imine bond in α,β-unsaturated imine substrates to afford unsaturated amine compounds.
BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF
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Paragraph 0276, (2016/02/28)
Disclosed herein are antimicrobial compounds compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to boronic acid derivatives and their use as therapeutic agents.
Synthesis of 3-vinylpiperidines, 3-ethylidenepiperidines and 5-functionalized-1,2,3,4-tetrahydropyridines
Aelterman, Wim,De Kimpe, Norbert
, p. 2563 - 2574 (2007/10/03)
Reaction of 1-azapentadienyl anions, generated by deprotonation of N-(2-buten-1-ylidene-)-alkylamines, with l-bromo-3-chloropropane led to the formation of N-[2-(3-chloropropyl)-3-buten-1-ylidene]alkylamines. By reaction with nucleophiles and bases, the latter functionalized imines were converted into unsaturated piperidines, i.e. 3-vinylpiperidines, 3-ethylidenepiperidines, 5-vinyl-1,2,3,4-tetrahydropyridines and 5-(2-cyanoethyl)-1,2,3,4-tetrahydropyridines. 5-Vinyl-1,2,3,4-tetrahydropyridines proved to be suitable dienes in Diels-Alder reactions with N-phenylmaleimide, giving rise to octahydro-1H-pyrrolo[3,4h]quinoline-1,3-diones.
Exclusive γ-regio functionalization of crotonaldehyde using γ-trimethylsilyl crotonaldimine. Application to the one pot synthesis of conjugated dienals
Bellassoued,Salemkour
, p. 4607 - 4624 (2007/10/03)
Cesium fluoride mediated reaction of γ-trimethylsilyl N-tert-butyl crotonaldimine 9 with a wide range of aldehydes takes place in DMSO at room temperature and affords exclusive γ-regio functionalized products. Heating (rt to 100°C) the δ-silyloxy imines 11 thus obtained leads, after very mild hydrolysis of the tert-butylimine function, to the conjugated dienals 14 in good yields and with excellent (E,E)-selectivities.
On the Structures of 1-Azapentadienyllithium Compounds
Wolf, Gerhard,Wuerthwein, Ernst-Ulrich
, p. 889 - 896 (2007/10/02)
1-Azapentadienyllithium compounds 2 - 6 have been prepared by deprotonation of the α,β-unsaturated imines 1 with lithium diisopropylamide.Their structures in THF solution at various temperatures have been studied by 1H- and 13C-NMR spectroscopy.All N-alky
Reactions of 1-aza-1,3-butadienes. A novel synthesis of 6-acetyl- and 6-methoxycarbonyl-5-methyl-2-cyclohexenones
Geirsson,Gudmundsdottir
, p. 993 - 994 (2007/10/02)
The readily available N-tert-butyl-1-aza-1,3-pentadiene [N-(2-butenylidene)-2-methyl-2-propylamine] reacts with acetylacetone and methyl acetoacetate under acid-catalyzed reaction conditions to afford 6-acetyl- and 6-methoxycarbonyl-5-methyl-2-cyclohexenones, respectively, in good yield.
The Reaction of α,β-Unsaturated Aldimines with Benzofuroxan
Devi, Purabi,Sandhu, Jagir S.
, p. 427 - 428 (2007/10/02)
Benzofuroxan reacts with imines derived from crotonaldehyde and cinnamaldehyde, to form 2-iminomethylquinoxaline 1,4-dioxides.
