695166-97-3Relevant academic research and scientific papers
Water and fluorinated alcohol mediated/promoted tandem insertion/aerobic oxidation/bisindolylation under metal-free conditions: Easy access to bis(indolyl)methanes
Wang, Yong,Cao, Xinyi,Ji, Jingfei,Cui, Xiuling,Pi, Chao,Zhao, Leyao,Wu, Yangjie
supporting information, p. 1696 - 1700 (2021/03/08)
A green tandem reaction, including insertion/aerobic oxidation/bisindolylation, starting from indoles and diazo compounds has been developed. The combination of water and fluorinated alcohol plays dual roles as solvent and promoter in this chemical transformation. Molecular oxygen in the air acts as an oxidant. 3,3′-Bis(indolyl)methanes with quaternary carbon were produced under metal-free conditions. No any catalyst and additive were required. N2 and water were released as sole by-products. Absence of water and fluorinated alcohol resulted in Wolff rearrangement product.
Synthetic method of novel indole-containing compound
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Paragraph 0012; 0013, (2016/10/07)
The invention discloses a preparation method of an indole-containing compound. An ethylbenzene compound and an indole compound serve as the raw materials, and a product containing the indole compound is generated through a reaction under the condition of heating. According to the preparation method, the raw materials are easy to obtain, operation is convenient and safe, and the reaction yield is high. The indole compound has very high practical value and social and economic benefits.
Direct Regioselective Oxidative Cross-Coupling of Indoles with Methyl Ketones: A Novel Route to C3-Dicarbonylation of Indoles
Gao, Qinghe,Zhang, Jingjing,Wu, Xia,Liu, Shan,Wu, Anxin
, p. 134 - 137 (2015/07/28)
The first C3-dicarbonylation of indoles was realized through direct oxidative cross-coupling of indoles with methyl ketones in the presence of molecular iodine and pyrrolidine. This reaction constructed a highly efficient indolyl diketones scaffold, which
Intramolecular Pd-catalyzed C-H functionalization: Construction of fused tetracyclic bis-indole alkaloid analogues
Chu, Xue-Qiang,Zi, You,Lu, Xin-Mou,Wang, Shun-Yi,Ji, Shun-Jun
, p. 232 - 238 (2014/01/06)
An efficient Pd-catalyzed intramolecular indole-C2-arylation protocol for the synthesis of pharmaceutically active bis-indole alkaloid analogues from simple and readily available and 3,3′-Bis(1H-indol-3-yl)methanes derivatives has been developed. The corresponding products could be obtained in moderate to excellent yields, which permits selective modification on either one of the two indole moieties independently.
I2-promoted direct one-pot synthesis of 2,2-bisindolyl-1- arylethanones from multiform substrates arylethenes, 2-hydroxy-aromatic ketones, and carbinols
Jia, Feng-Cheng,Zhu, Yan-Ping,Liu, Mei-Cai,Lian, Mi,Gao, Qing-He,Cai, Qun,Wu, An-Xin
supporting information, p. 7038 - 7044 (2013/07/26)
An I2-promoted domino protocol was developed to construct 2,2-bisindolyl-1-arylethanones from multiform substrates arylethenes, 2-hydroxy-aromatic ketones, and carbinols via three distinct pathways. Through a logical coupled oxidation/Friedel-Crafts alkylation domino process, a variety of 2,2-bisindolyl-1-arylethanones were synthesized in one-pot.
Metal-free sp3 C-H bond dual-(Het)arylation: I 2-promoted domino process to construct 2,2-bisindolyl-1-arylethanones
Zhu, Yan-Ping,Liu, Mei-Cai,Jia, Feng-Cheng,Yuan, Jing-Jing,Gao, Qing-He,Lian, Mi,Wu, An-Xin
supporting information; experimental part, p. 3392 - 3395 (2012/09/08)
A molecular I2-promoted sp3 C-H bond dual-(het)arylation protocol was developed for the synthesis of 2,2-bisindolyl-1-arylethanones. Through a logical design, three mechanism-different reactions (iodination, Kornblum oxidation, and F
