695186-53-9Relevant academic research and scientific papers
Synthetic route to a benzooxazole derivative with heparanase inhibitory activity
Da Pieve, Chiara,Patel, Pravin,Missailidis, Sotiris
, p. 518 - 522 (2010)
The synthesis of a benzooxazol-5-yl acetic acid derivative (9) with strong heparanase and angiogenesis inhibitory activity, and thus possible commercial interest, is described in detail. Copyright Taylor & Francis Group, LLC.
Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: Novel classes of heparanase inhibitor
Courtney, Stephen M.,Hay, Philip A.,Buck, Richard T.,Colville, Claire S.,Phillips, David J.,Scopes, David I.C.,Pollard, Faye C.,Page, Martin J.,Bennett, James M.,Hircock, Margaret L.,McKenzie, Edward A.,Bhaman, Maina,Felix, Robert,Stubberfield, Colin R.,Turner, Paul R.
, p. 2295 - 2299 (2007/10/03)
Using a furanylthiazole acetic acid as a starting point, a novel series of benzoxazol-5-yl acetic acid derivatives have been identified as heparanase inhibitors. Several compounds possess an IC50 of ～200 nM against heparanase, for example, tran
PHARMACEUTICALLY ACTIVE BENZOXAZOLE, BENZTHIAZOLE AND BENZIMIDAZOLE ACID DERIVATIVES
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Page 24, (2010/02/07)
Compounds of formula (I): wherein R1, R2 and R3 are independently, hydrogen, halogen, CF3, OR6, NR7R8, NR8COR10, NR8SO2R10 or C1-6 alkyl optionally substituted by hydroxy, C1-6 alkoxy or NR7R8; R4 is NR8CONR8R9, NR8COR9, NR8SO2R9, or W-CONR8R9, where W is a bond, C1-6 alkylene, C2-6 alkenylene or C2-6 alkynylene; and R5 is Formula (A) methods for their synthesis, pharmaceutical compositions comprising them and their use in medicine, in particular for the treatment of cancer.
