69538-75-6Relevant academic research and scientific papers
One-Pot Synthesis of 3-Cyano-2-pyridones
Wang, Yingcai,Liu, Gang,Reyes, Jeremy Chris P.,Duverna, Randolph
, p. 1185 - 1191 (2015/08/06)
A versatile synthesis of 3-cyano-2-pyridones via a one-pot, four-component condensation of ethyl cyanoacetate, ketones, aldehydes, and ammonium acetate under very mild conditions has been developed. This method provides rapid access to this type of valuab
Cascade synthesis of 2-pyridones using acrylamides and ketones
Rai, Sunil K.,Khanam, Shaziya,Khanna, Ranjana S.,Tewari, Ashish K.
, p. 44141 - 44145 (2015/02/02)
Microwave assisted non-catalytic condensation of 2-cyanoacetamide with aromatic aldehydes, and enolate mediated Michael-type addition to acrylamide followed by oxidative cyclization, produce 2-pyridones in good to excellent yield. Unsymmetrical ketones produce two regioisomeric enolates, therefore thermodynamic and kinetic products of butan-2-one and pentan-2-one have been isolated and fully characterized. This journal is
Microwave-assisted synthesis of 2(1H)-pyridones and their glucosides as cell proliferation inhibitors
Al-Neyadi, Shaikha S.,Hassan, Ahmed H.,Abdou, Ibrahim M.
experimental part, p. 120 - 134 (2011/10/09)
A new series of substituted 2(1H)-pyridones (4a-i) and their glucosides (5, 6a-e) were prepared as potential agents against leukemia (HL-60) cells. Glucosides (5,6a-e) were synthesized using three independent methods. Microwave protocol as an ecologically
One-pot synthesis of 4,6-diaryl-2-oxo-1,2-dihydropyridine-3-carbonitriles via three-component cyclocondensation under solvent-free conditions
Rong, Liangce,Han, Hongxia,Jiang, Hong,Shi, Daqing,Tu, Shujiang
, p. 217 - 224 (2008/03/17)
An efficient and facile synthesis of 4,6-diaryl-2-oxo-1,2-dihydropyridine- 3-carbonitriles via three-component cyclocondensation from aromatic aldehydes, aromatic ketones, and 2-cyanoacetamide under solvent-free conditions is described. The mild reaction
An efficient and facile procedure for the synthesis of 4,6-diaryl-2(1H)- pyridones under solvent-free conditions
Rong, Liangce,Wang, Haiying,Shi, Jingwen,Yang, Fang,Yao, Hao,Tu, Shuajiang,Shi, Daqing
, p. 1505 - 1508 (2008/09/18)
(Chemical Equation Presented) An efficient and convenient method for the preparation of 4,6-diaryl-2(1H)-pyridones by the one-pot reaction of aromatic aldehydes, aromatic ketones and malononitrile, in the presence of sodium hydroxide under solvent-free co
An efficient and facile synthesis of 2-amino-4,6-diarylbenzene-1,3- dicarbonitrile and 1,2-dihydro-2-oxo-4,6-diarylpyridine-3-carbonitrile under solvent-free conditions
Rong, Liangce,Li, Xiaoyue,Wang, Haiying,Shi, Daqing,Tu, Shujiang
, p. 1314 - 1315 (2008/02/05)
A one-pot three-component condensation of aromatic aldehyde, aromatic ketone, and malononitrile leading to an efficient synthesis of 2-amino-4,6-diarylbenzene-1,3-dicarbonitrile and 1,2-dihydro-2-oxo-4,6- diarylpyridine-3-carbonitrile has been carried out
A simple and convenient synthesis of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones under solvent-free microwave conditions
Dave, Chaitanya G.,Shah, Dhaval A.,Agrawal, Yadvendra K.
, p. 885 - 887 (2007/10/03)
A rapid and efficient method for the preparation of 4,6-disubstituted 3-cyanopyridin-2(1H)-ones by the reaction between 1,3-diarylpropen-1-ones and cyanoacetamide using powdered potassium hydroxide under microwave irradiation is reported. Excellent yields and higher purity are obtained in this solvent free one pot synthesis as compared to conventional methods.
Reactions of Malononitrile with Acetylenic Esters and Ketones
Kandeel, Kamal A.,Vernon, John M.,Dransfield, Trevor A.,Fouli, Fouli A.,Youssef, Ahmed S. A.
, p. 2101 - 2117 (2007/10/02)
The addition of malononitrile to acetylenic esters and acetylenic ketones catalysed by sodium alkoxides leads to the formation of 3- and 5-cyano-2-pyridones, 2-cyano- and 2,6-dicyano-aniline derivatives, and other products.
