6954-55-8

Usage

Chemical Properties

beige powder

Uses

Fluorene-4-carboxylic acid is used in pharmaceutical industry.

General Description

The structures of two phases of fluorene-4-carboxylic acid from room-temperature growths were studied.

InChI:InChI=1/C14H10O2/c15-14(16)12-7-3-5-10-8-9-4-1-2-6-11(9)13(10)12/h1-7H,8H2,(H,15,16)/p-1

Upstream product

• 7071-85-4 9-hydroxy-fluorene-4-carboxylic acid 
• 7553-56-2 iodine 
• 64-19-7 acetic acid 
• 863305-32-2 diphenic acid 
• 6223-83-2 9-oxo-9H-fluorene-4-carboxylic acid 

Downstream Products

• 141606-44-2 fluorene-4-carbonitrile 
• 99585-29-2 5-Hydroxy-2-nitrofluorene 
• 95303-05-2 2,4,5-Trichlorophenyl 9-(Hydroxymethyl)fluorene-4-carboxylate 
• 403987-26-8 C₃₆H₃₇N₃O₂ 
• 403987-27-9 C₃₆H₃₇N₃O₂ 
• 403987-25-7 C₄₀H₃₇N₃O₂ 
• 28322-01-2 fluorene-4-carboxamide 
• 7071-89-8 2,5-diaminofluorene 
• 54147-65-8 5-nitrofluorenone-4-carboxylic acid 
• 7256-04-4 7-nitro-fluorene-4-carboxylic acid 
• 16218-33-0 2-Jod-fluoren-5-carbonsaeure 
• 1556-99-6 4-methylfluorene 
• 6223-83-2 9-oxo-9H-fluorene-4-carboxylic acid 
• 7315-93-7 fluorene-4-carboxylic acid chloride 

Relevant academic research and scientific papers

Nitroaromatics as n-type organic semiconductors for field effect transistors

The nitro group (NO2) is one of the most common electron-withdrawing groups but it has rarely been used in the design of organic semiconductors (OSCs). Herein, we report the n-type semiconducting behavior of simple fluorenone derivatives functionalized with NO2and CN groups. While the electron mobilities measured in the thin film field-effect transistors are modest (10?6-10?4cm2V?1s?1), the nitrofluorenone OSCs offer excellent air-stability and remarkable tunability of energy levelsviafacile modification of the substitution pattern. We study the effect of substituents on the electrochemical properties, molecular and crystal structure, and the charge transport properties of nitrofluorenones to revitalize the underestimated potential of NO2functionalization in organic electronics.

Polymer-des-ethyl sunitinib conjugates

The invention relates to (among other things) polymer-des-ethyl sunitinib conjugates and related compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over des-ethyl sunitinib in unconjugated form.

Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives

The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions of compounds of Formula (A): wherein Ar, Y, R1 and q are as defined herein; and their use in the treatment of diseases, including treatment of sleepiness, promotion of wakefulness, treatment of Parkinson's disease, cerebral ischemia, stroke, sleep apneas, eating disorders, stimulation of appetite and weight gain, treatment of attention deficit hyperactivity disorder ("ADHD"), enhancing function in disorders associated with hypofunctionality of the cerebral cortex, including, but not limited to, depression, schizophrenia, fatigue, in particular, fatigue associated with neurologic disease, such as multiple sclerosis, chronic fatigue syndrome, and improvement of cognitive dysfunction.

Preneoplastic lesions, DNA adduct formation and mutagenicity of 5-, 7- and 9 -hydroxy-2-nitrofluorene, metabolites of the air pollutant 2-nitrofluorene

The metabolites of 2-nitrofluorene (NF), 5-, 7- and 9-OH-2-nitrofluorene (OH-NF) were compared for their genotoxicity. Seventy-two hours after intraperitoneal administration of these substances individually to rats (100 mg/kg body wt.), DNA adducts in liver tissue were analyzed with 32P-TLC and 32P-HPLC. An in vivo liver model was used to test the initiating capacity of the said substances for the formation of preneoplastic lesions. 5-OH-NF showed low capacity to induce DNA adduct formation and low potential as initiator to induce preneoplastic lesions-foci/nodules in the liver of rats. Both 7- and 9-OH-NF induced DNA adducts and preneoplastic liver lesions but with smaller quantities compared to NF. It seems that 7- and 9-OH-NF can not be considered as detoxification products of NF. In general, the initiating capacity of these substances for the formation of preneoplastic lesions has a good correlation with their potency to form DNA adducts.

Synthesis of 4H-Cyclopentaphenanthrene from Fluorene Skeleton

4-Fluoreneacetic acid was prepared and its chloride was cyclized with AlCl3 to give 4H-cyclopentaphenanthren-8-ol accompanied by the 8,9-dione.These were both reduced to 4H-cyclopentaphenanthrene: the overall yield was 40-50percent from diphenic acid.The phenol was converted to acetoxy and amino substrates.