6954-69-4

Usage

Uses

Used in Pharmaceutical Industry:
2,5-DIMETHYL-4-NITRO ACETANILIDE is used as an analgesic and anti-inflammatory agent for the treatment of conditions characterized by pain and inflammation, such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. It is effective in reducing inflammation and alleviating pain by inhibiting the production of prostaglandins, which are chemicals that mediate inflammation and pain responses.
Used in Medical Treatments:
2,5-DIMETHYL-4-NITRO ACETANILIDE is used as a therapeutic agent for managing fever and reducing fever-induced discomfort. Its antipyretic properties help in lowering elevated body temperatures, providing relief in cases of fever.
Used in Topical Pain Relief:
In addition to oral administration, 2,5-DIMETHYL-4-NITRO ACETANILIDE is used in topical forms such as gels and patches for localized pain relief. This allows for targeted treatment of pain in specific areas of the body, reducing systemic side effects and enhancing patient comfort.
While 2,5-DIMETHYL-4-NITRO ACETANILIDE is generally well-tolerated, its use may be accompanied by potential side effects, including stomach irritation, dizziness, and headache. It is important for patients to consult with healthcare professionals to ensure safe and effective use of 2,5-DIMETHYL-4-NITRO ACETANILIDE.

InChI:InChI=1/C10H12N2O3/c1-6-5-10(12(14)15)7(2)4-9(6)11-8(3)13/h4-5H,1-3H3,(H,11,13)

Upstream product

• 2050-44-4 N-(2,5-dimethylphenyl)acetamide 
• 7697-37-2 nitric acid 
• 95-78-3 2,5-Dimethylaniline 
• 75-36-5 acetyl chloride 
• 3460-29-5 4-nitro-2,5-xylidine 

Downstream Products

• 3460-29-5 4-nitro-2,5-xylidine 
• 857616-55-8 acetic acid-(2,5-dimethyl-4-nitro-N-nitroso-anilide) 
• 6393-01-7 2,5-Dimethyl-1,4-phenylenediamine 
• 81115-43-7 6-methyl-5-nitro-1H-indazole 
• 81115-45-9 6-methyl-1H-indazole-5-amine 
• 106423-99-8 2,2′,5,5′-tetramethyl-4,4′-azodiacetanilide 
• 23410-20-0 2,5-dimethyl-4-aminoacetanilide 
• 15540-81-5 1-bromo-2,5-dimethyl-4-nitrobenzene 

Relevant academic research and scientific papers

FORMIMIDAMIDINE COMPOUNDS USEFUL AGAINST PHYTOPATHOGENIC MICROORGANISMS

The present invention relates to 4-substituted amidine derivatives of the general formula (I), wherein A1-A4, D, L, Q, R7, R7' and integer's v and w have the meanings as defined in description. The invention further relates to methods for their preparation and use of said compounds to fight undesired phytopathogenic microorganisms, and agents for said purpose, comprising said amidine derivatives, all according to the invention. This invention further relates to a method for controlling undesired phytopathogenic microorganisms by application of said 4-substituted amidine derivatives of general formula (I) to such undesired microorganisms and/or to their habitat, according to the invention. (I)

Variable noninnocence of substituted azobis(phenylcyanamido)diruthenium complexes

The synthetic chemistry of substituted 4,4′-azobis(phenylcyanamide) ligands was investigated, and the complexes [{Ru(tpy)(bpy)}2( μ-L)][PF6]2, where L = 2,2′:5,5′-tetramethyl-4,4′-azobis(phenylcyanamido) (Me4adpc2-), 2,2′-dimethyl-4,4′-azobis(phenylcyanamido) (Me2adpc2-), unsubstituted (adpc2-), 3,3′-dichloro-4,4′-azobis(phenylcyanamido) (Cl2adpc2-), and 2,2′:5,5′-tetrachloro-4,4′-azobis(phenylcyanamido) (Cl4adpc2-), were prepared and characterized by cyclic voltammetry and vis-near-IR (NIR) and IR spectroelectrochemistry. The room temperature electron paramagnetic resonance spectrum of [{Ru(tpy)(bpy)}2( μ-Me4adpc)]3+ showed an organic radical signal and is consistent with an oxidation-state description [RuII, Me4adpc?-, RuII]3+, while that of [{Ru(tpy)(bpy)}2( μ-Cl2adpc)]3+ at 10 K showed a low-symmetry RuIII signal, which is consistent with the description [RuIII, Cl2adpc2-, RuII]3+. IR spectroelectrochemistry data suggest that [{Ru(tpy)(bpy)}2( μ-adpc)]3+ is delocalized and [{Ru(tpy)(bpy)}2( μ-Cl2adpc)]3+ and [{Ru(tpy)(bpy)}2( μ-Cl4adpc)]3+ are valence-trapped mixed-valence systems. A NIR absorption band that is unique to all [{Ru(tpy)(bpy)}2( μ-L)]3+ complexes is observed; however, its energy and intensity vary depending on the nature of the bridging ligand and, hence, the complexes oxidation-state description.

5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS

Described herein are compounds of formula I: wherein G is and pharmaceutically acceptable salts thereof, wherein J, X, R1, R2, R11, R12' and p are as defined herein. Also provided herein are methods of making the compounds of formula I, and methods of using these compounds for inhibiting or treating a pathological condition or disorder linked to or mediated by a protein kinase in a mammal.

Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents

This invention relates to 2-arylimino heterocycles, including 2-arylimino-1,3-thiazolidines, 2-arylimino-2,3,4,5-tetrahydro-1,3-thiazines, 2-arylimino-1,3-thiazolidin-4-ones, 2-arylimino-1,3-thiazolidin-5-ones, and 2-arylimino-1,3-oxazolidines, and their use in modulating progesterone receptor mediated processes, and pharmaceutical compositions for use in such therapies.

Ozone-mediated Reaction of Anilides and Phenyl Esters with Nitrogen Dioxide: Enhanced Ortho-reactivity and Mechanistic Implications

In the presence of ozone, anilides 1 can be nitrated rapidly with nitrogen dioxide in chloroform at 0 deg C to give a high proportion of ortho-nitro derivatives (ortho:para = 1.2-4.4) in good yields.The phenyl esters 15 can be similarly nitrated on the aromatic ring without significant cleavage of the ester bond, giving a mixture of isomeric nitro derivatives in which the ortho-isomer predominantes (ortho:para = 1.1-1.5).The oridin of the enhanced ortho reactivity is discussed in terms of an electron-transfer process involving the nitrogen trioxide as initial electrophile.

Ortho-Selective Nitration of Acetanilides with Nitrogen Dioxide in the Presence of Ozone

In the presence of ozone, nitrogen dioxide rapidly reacts with acetanilides ortho-selectively at low temperatures, giving a high proportion of ortho-nitro derivatives in good yields.

Process for the preparation of p-nitroaniline compounds by the alkaline hydrolysis of mixed anilides

Process for the preparation of certain substituted p-nitroaniline compounds essentially free of the corresponding o-nitroaniline compounds. The process comprises subjecting an alkanol solution of the anilides of such compounds to alkaline hydrolysis conditions, thereby effecting hydrolysis and precipitation of the p-nitroaniline compound essentially free of the undesired o-isomer. The compounds are intermediates useful in the preparation of azo pigments.