6393-01-7

Usage

Uses

Used in Polymer Synthesis:
2,5-Dimethyl-1,4-benzenediamine is used as a reagent for the synthesis of novel Schiff-base type conjugative polymers. Its unique structure allows it to participate in condensation reactions, leading to the formation of polymers with specific properties and potential applications in various fields.
Used in Chemical Research:
In the field of chemical research, 2,5-Dimethyl-1,4-benzenediamine serves as a valuable intermediate for the development of new compounds and materials. Its ability to form Schiff bases and participate in various chemical reactions makes it a versatile component in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
2,5-Dimethyl-1,4-benzenediamine may also find applications in the pharmaceutical industry, where it can be used as a precursor for the synthesis of various drug molecules. Its reactivity and structural features can contribute to the development of new therapeutic agents with improved efficacy and selectivity.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 2,5-Dimethyl-1,4-benzenediamine can be utilized for the production of dyes and pigments with specific color properties. Its ability to form conjugated systems and participate in various chemical reactions can lead to the development of novel dyes and pigments with unique characteristics.
Overall, 2,5-Dimethyl-1,4-benzenediamine is a versatile compound with a wide range of applications in various industries, including polymer synthesis, chemical research, pharmaceuticals, and dyes and pigments. Its unique structure and reactivity make it a valuable component in the development of new materials and compounds.

InChI:InChI=1/C8H12N2/c1-5-3-8(10)6(2)4-7(5)9/h3-4H,9-10H2,1-2H3

Upstream product

• 53877-41-1 4-(2,5-dimethyl-phenylazo)-2,5-dimethyl-aniline 
• 36164-92-8 2,5-dimethyl-p-benzoquinone dioxime 
• 872277-83-3 2,5-dimethyl-4-nitroso-aniline 
• 3460-29-5 4-nitro-2,5-xylidine 
• 136-21-0 4-(2,4-dimethyl-phenylazo)-2,5-dimethyl-aniline 
• 99069-08-6 Diamino-β-cumidinsaeure 
• 7647-01-0 hydrogenchloride 
• 95-78-3 2,5-Dimethylaniline 
• 861309-25-3 (4-amino-2,5-dimethyl-phenyl)-hydrazine-N,N'-dicarboxylic acid diethyl ester 
• 10034-85-2 hydrogen iodide 
• 64-19-7 acetic acid 
• 137-18-8 2,5-Dimethyl-1,4-benzoquinone 
• 6954-69-4 N-(2,5-dimethyl-4-nitrophenyl)acetamide 
• 2050-44-4 N-(2,5-dimethylphenyl)acetamide 

Downstream Products

• 76806-38-7 2,5-dimethylphenylene-1,4-diisocyanate 
• 137-18-8 2,5-Dimethyl-1,4-benzoquinone 
• 103230-60-0 2,5-dimethyl-[1,4]benzoquinone-bis-chlorimin 
• 69950-87-4 C₁₈H₃₂N₄O₆P₂S₂ 
• 16349-71-6 3,3'-dimethyl-1,1'-(2,5-dimethyl-p-phenylene)-bis-thiourea 
• 98515-30-1 N,N'-(2,5-Dimethyl-1,4-phenylene)bis(cyanamide) 
• 712-32-3 1,4-Dimethyl-2,5-dinitrobenzol 
• 503864-14-0 2,5-dimethyl-1,4-bis-[(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidenemethyl)amino]benzene 
• 529-81-7 Troeger's base 

Relevant academic research and scientific papers

A 2,5-dimethyl -1,4-phenylene diamine method for the preparation of

The invention relates to a preparation method of 2,5-dimethyl-1,4-phenylenediamine. The method is characterized in that aniline substances are used as a raw material and are made into 2,5-dimethyl-1,4-phenylenediamine through a diazotization reaction, a coupled reaction, a hydrogenolysis reaction and purification treatment. According to the invention, the main and the auxiliary raw materials are cheap and easy to obtain, the reaction steps are relatively few, the yield is high, the operation is simple and convenient, and the method is used for further replacing the old technology to realize and develop the novel industrialized production of the product; the aniline substances are reclaimed to be still used as auxiliary raw materials for preparing aniline diazonium salt, so that cost and pollution are reduced, circular economy is produced, and cleaner production is realized; the quality of the obtained product is improved greatly, and the content is far more than the old product, especially an exported product of the content of 75%; the prepared product can not only be used for dye and paints, but also can expand using functions of a high-performance material monomer.

Structure-Activity and Structure-Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1-Nrf2 Protein-Protein Interaction Inhibitor

Directly disrupting the Keap1-Nrf2 protein-protein interaction (PPI) is an effective way to activate Nrf2. Using the potent Keap1-Nrf2 PPI inhibitor that was reported by our group, we conducted a preliminary investigation of the structure-activity and structure-property relationships of the ring systems to improve the drug-like properties. Compound 18e, which bore p-acetamido substituents on the side chain phenyl rings, was the best choice for balancing PPI inhibition activity, physicochemical properties, and cellular Nrf2 activity. Cell-based experiments with 18e showed that the Keap1-Nrf2 PPI inhibitor can activate Nrf2 and induce the expression of Nrf2 downstream proteins in an Nrf2-dependent manner. An exploratory in vivo experiment was carried out to further evaluate the anti-inflammatory effects of 18e in a LPS-challenged mouse model. The primary results indicated that 18e could reduce the level of circulating pro-inflammatory cytokines induced by LPS and relieve the inflammatory response. (Chemical Equation Presented).

Diamination of phenylene dihalides catalyzed by a dicopper complex

Diamination of phenylene dihalides with aqueous ammonia to give the corresponding phenylenediamines can be achieved by using a dicopper complex [Cu2(bpnp)(OH)(CF3COO)3] (1) (bpnp = 2,7-bis(pyridine-2-yl)-l,8-naphthyridine) as the catalyst in the presence of Bu4NBr and Cs2CO3 in high yields. In addition, 1,3,5-tribromobenzene was converted into benzenetriamine quantitatively under the same conditions. This method offers a new opportunity, particularly simplifying steps and increasing yields, for the preparation of aryl diamines.

Bis-Amination of Aryl Halides

Disclosed are methods for making 1,3- and 1,4-diamino-phenyl intermediates by utilizing bis-amination of ortho-substituted aryl halides.

1,3-Dihydroxybenzene derivatives and colorants containing said compounds

1,3-Dihydroxybenzene derivatives of general formula (I) or (Ia) or physiologically tolerated, water-soluble thereof wherein R′1 denotes substituted pyridyl group, a pyrimidyl group, a group of formula (IIa) or (IIIa) and the dyeing agents for keratin fibers containing these compounds.

One step hair coloring compositions using salts

A hair coloring composition comprising the following two compositions which are mixed just prior to application to the hair: (a) a composition comprising a water-soluble peroxygen oxidizing agent; and (b) a composition comprising one or more oxidative hair coloring agents selected from the group consisting of an aromatic diamine, an amino phenol, a naphthol, a polyhydric phenol, a catechol and mixtures thereof; wherein the composition comprising one or more oxidative hair coloring agents further comprises al least one water soluble carbonate releasing salts; and optionally a water soluble ammonium salt, is described.

Transition metal complexes as dye forming catalysts in hair coloring compositions

A hair coloring composition comprising a first composition which comprises: (a) a dye forming transition metal salt or complex; which is first applied to the hair; and a second composition which comprises the following two compositions which are mixed just prior to application to the hair: (a) a composition comprising a water-soluble peroxygen oxidizing agent; and (b) a composition comprising one or more oxidative hair coloring agents selected from the group consisting of an aromatic diamine, an aminophenol, a polyhydric phenol a catechol and mixtures thereof.

Enhanced color deposition for hair with sequestering agents

Hair coloring compositions which comprise: (A) non-nitrogenous chelating agents from the group consisting of polyphosphate; phosphonates; hydroxycarboxylates; polyacrylates; zeolite; and mixtures thereof; (B) an oxidative dye primary intermediate; and (C) an oxidative dye coupler; (D) and water are described. The present invention also relates to a method for coloring hair which comprises contacting said hair with a hair coloring composition as described above.

Process for dyeing keratinous fibers with aminoindoles and oxidation dye precursors at basic Ph's and dyeing agents

The invention relates to a process for dyeing keratinous fibres, which consists in applying to these fibres a composition containing, in a suitable medium for dyeing, at least one coupler of formula: STR1 where R1 denotes hydrogen or alkyl, R2 and R3 denote hydrogen, alkyl, COOR' where R' is alkyl or hydrogen, at least one of the groups R2 and R3 denoting hydrogen, R4 denotes hydrogen, alkyl, hydroxyalkyl, polyhydroxyalkyl or aminoalkyl, Z1 and Z2 denote hydrogen, alkyl, hydroxyl, halogen, alkoxy, at least one of the groups Z1 and Z2 is other than hydrogen at least one oxidation dye precursor, at least one oxidizing agent, the pH of the composition applied to the fibres being higher than 7.

Methods for dyeing keratinous fibers with compositions which contain aminoindole couplers, oxidation dye precursors, and oxidizing agents at acid pHs

A method for dyeing keratin fibers, wherein a composition is applied to said fibers which contains, in a suitable dyeing medium, at least one coupler having formula (I) STR1 wherein R1 is hydrogen or alkyl; R2 and R3 are hydrogen, alkyl, COOR', where R' is alkyl or hydrogen; R4 is hydrogen, hydroxyalkyl, alkyl, polyhydroxyalkyl or acetyl or aminoalkyl wherein the amine may be mono- or disubstituted by alkyl; Z1 and Z2 are hydrogen, alkyl, hydroxy, halogen, alkoxy or a salt thereof; at least one precursor of an oxidation hair dye; and at least one oxidizing agent, the pH of the composition applied to the fibers being less than 7.