69547-87-1Relevant academic research and scientific papers
Resolving a Reactive Organometallic Intermediate from Dynamic Directing Group Systems by Selective C?H Activation
Schaufelberger, Fredrik,Timmer, Brian J. J.,Ramstr?m, Olof
, p. 101 - 104 (2018)
Catalyst discovery from systems of potential precursors is a challenging endeavor. Herein, a new strategy applying dynamic chemistry to the identification of catalyst precursors from C?H activation of imines is proposed and evaluated. Using hydroacylation of imines as a model reaction, the selection of an organometallic reactive intermediate from a dynamic imine system, involving many potential directing group/metal entities, is demonstrated. The identity of the amplified reaction intermediate with the best directing group could be resolved in situ by ESI-MS, and coupling of the procedure to an iterative deconvolution protocol generated a system with high screening efficiency.
Rhodium-catalyzed intermodular hydroiminoacylation of alkenes: Comparison of neutral and cationic catalytic systems
Marce, Patricia,Godard, Cyril,Feliz, Marta,Yanez, Xiomara,Bo, Carles,Castillon, Sergio
, p. 2976 - 2985 (2009/10/23)
Both cationic and neutral rhodium catalytic systems for the hydroiminoacylation of alkenes were studied using NMR spectroscopy and DFT-based methods. With neutral systems, the oxidative addition step was shown to be thermodynamically favored. With the cat
