6955-57-3

Basic information

• Product Name: phenylphosphoramidic dichloride
• CAS NO: 6955-57-3
• Molecular Formula: C₆H₆Cl₂NOP
• Molecular Weight: 209.9977
• Mol File: 6955-57-3.mol

Chemical Properties

• Boiling Point: 282.8°C at 760 mmHg
• Flash Point: 124.8°C
• Density: 1.507g/cm³
• Vapor Pressure: 0.00328mmHg at 25°C
• Refractive Index: 1.602
• CAS DataBase Reference: phenylphosphoramidic dichloride(CAS DataBase Reference)
• NIST Chemistry Reference: phenylphosphoramidic dichloride(6955-57-3)
• EPA Substance Registry System: phenylphosphoramidic dichloride(6955-57-3)

Safety Data

• Hazardous Substances Data: 6955-57-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Phenylphosphoramidic dichloride is used as a reagent in organic synthesis for the preparation of phosphoramidate esters. Its high reactivity allows for the formation of various chemical compounds, making it a valuable component in the synthesis process.
Used in Flame Retardant Production:
In the flame retardant industry, phenylphosphoramidic dichloride is used as a key component in the production of flame retardants. These flame retardants are incorporated into various materials to enhance their fire resistance and safety properties.
Used in Pesticide Production:
Phenylphosphoramidic dichloride is utilized in the manufacturing process of certain pesticides. Its reactivity and ability to form stable compounds make it a suitable ingredient for developing effective pest control agents.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, phenylphosphoramidic dichloride is employed as a reagent in the synthesis of various pharmaceutical compounds. Its versatility in organic synthesis contributes to the development of new drugs and therapeutic agents.
As a hazardous chemical, phenylphosphoramidic dichloride requires proper handling, storage, and disposal to minimize its potential risks to human health and the environment.

Upstream product

• 142-04-1 aniline hydrochloride 
• 62-53-3 aniline 
• 10025-87-3 trichlorophosphate 
• 71-43-2 benzene 
• 618-36-0 rac-methylbenzylamine 

Downstream Products

• 93263-80-0 (2-oxo-2λ⁵-[1,3,2]diazaphosphinan-2-yl)-phenyl-amine 
• 30546-44-2 C₁₃H₁₄ClN₂OP 
• 89387-96-2 S,S-diphenyl phosphoranilidodithioate 
• 110715-43-0 (3S,7aS)-3-anilino-1,2,5,6,7,7a-hexahydropyrrolo<1,2-c><1,3,2>diazaphosphole 3-oxide 
• 110638-60-3 3-anilino-1,2,5,6,7,7a-hexahydropyrrolo<1,2-c><1,3,2>diazaphosphole 3-oxide 
• 7647-01-0 hydrogenchloride 
• 86119-84-8 phosphoric acid 
• 62-53-3 aniline 
• 13824-04-9 2,4-dianilino-1,3-diphenyl-cyclodiphosphazane-2,4-dioxide 
• 10025-87-3 trichlorophosphate 
• 65620-43-1 N-phenyl-N',N''-bis(morpholinyl)phosphoric triamide 
• 1402821-10-6 C₁₈H₁₆N₇O₂P 
• 1402821-09-3 C₂₀H₁₈N₅O₂P 
• 6952-96-1 racemic 2-anilino-2-oxo-1,3,2-oxazaphosphorinane 

Relevant articles and documents

Metal-Free Synthesis of N-Aryl-Substituted Azacycles from Cyclic Ethers Using POCl3

A facile method for the synthesis of N-aryl-substituted azacycles from arylamines and cyclic ethers has been developed. In this study, arylamines were treated with cyclic ethers in the presence of POCl3 and DBU to provide five- A nd six-membered azacycles. Using this method, various azacycloalkanes, isoindolines, and tetrahydroisoquinolines were prepared in high yields. This synthetic method offers an efficient approach to the production of azacycles from cyclic ethers.

Design, synthesis, and biological evaluation of phosphoramide derivatives as urease inhibitors

The design, synthesis, and biological evaluation of phosphoramide derivatives as urease inhibitors to reduce the loss of ammonia has been carried out. Forty phosphorus derivatives were synthesized and their inhibitory activities evaluated against that of jack bean urease. In addition, in vivo assays have been carried out. All of the compounds were characterized by IR, 1H NMR, MS, and elemental microanalysis. In some cases, detailed molecular modeling studies were carried out, and these highlighted the interaction between the enzyme active center and the compounds and also the characteristics related to their activity as urease inhibitors. According to the IC50 values for in vitro inhibitory activity, 12 compounds showed values below 1 μM and 8 of them represent improvements of activity in comparison to the commercial urease inhibitor N-n-butylthiophosphorictriamide (NBPT) (100 nM) (AGROTAIN). On the basis of the activity results and the conclusions of the molecular modeling study, a structural model for new potential inhibitors has been defined.

2-AMINO-1,3,2λ5-OXAZAPHOSPHORINANE 2-OXIDES

1,3,2λ5- oxazaphosphorinane 2-oxide derivatives were obtained by phosphorylation of amines and amino acid esters.A method for synthesizing pure enantiomers of 2-phenylamino-1,3,2λ5-oxazaphosphorinane 2-oxide was elaborated.

CONFORMATIONS OF SATURATED SIX-MEMBERED-RING PHOSPHORUS HETEROCYCLES. SYNTHESES AND X-RAY CRYSTAL STRUCTURES OF THREE 2-ANILINO-2-OXO-5,5-DIMETHYL-1,3,2-OXAZAPHOSPHORINANES

Single-crystal X-ray structural determinations have been made on 2-anilino-2-oxo-5,5-dimethyl-1,3,2-oxazaphosphorinane, 1; 2-(4-fluoroanilino)-2-oxo-5,5-dimethyl-1,3,2-oxazaphosphorinane, 2; and 2-(4-dimethylaminoanilino)-2-oxo-5,5-dimethyl-1,3,2-oxazaphosphorinane, 3.Compounds 1 and 2 are isostructural and crystallize in the monoclinic space group P21/c with four molecules per unit cell.The cell dimensions for 1 are: a = 12.234(4) Angstroem, b = 8.891(3) Angstroem, c = 12.152(4) Angstroem, and B = 110.77(4) deg.The cell dimensions for 2 are: a = 12.505(1) Angstroem, b = 8.919(1) Angstroem, c = 12.211(1) Angstroem, and B = 109.14(1) deg.Compound 3 crystallizes in the monoclinic space group P21/n with four molecules per unit cell of dimensions a = 6.321(2) Angstroem, b = 19.963(3) Angstroem, c = 12.236(2) Angstroem, and B = 104.89(4) deg.Full-matrix least-squares refinement for each of the structures led to conventional R factors of 5.1percent for 1, 4.9percent for 2, and 9.5percent for 3.The conformation adopted by 1 and 2 is the chair conformation with the anilino substituent axial.Compound 3 adopts the alternative chair conformation with an equatorially disposed anilino substituent.Structural variations are found which can be attributed to the operation of exo and endo anomeric effects.

Contributions to the Chemistry of Boron, 138. N-Borylated Derivatives of Phosphoric Amides: Examples of Intermolecular Borotropy

(Phosphorylamino)boranes of the type X2P(O)-NR'-BR2 (1-10) as well as 3B (11) have been prepared by several methods.Monomeric compounds are present in solution for X=R=N(CH3)2 and borotropic isomers X2P(NR')-O-BR2 were detected for X=Cl, N(CH3)2 and R=CH3.The borotropic equilibrium is established intermolecularly via dimers.This equilibrium lies fully on the side of the dimers for X=R=Cl and X=Cl, R=Br, respectively.This was ascertained for 2 (16) by an X-ray structure determination: the monomeric unit dimerizes to a molecule containing an eight-membered ring having a chair-like conformation.