6956-54-3

Usage

Physical state

Colorless liquid

Molecular weight

146.18 g/mol

Uses

Solvent
Intermediate in the production of other chemicals
Synthesis of active ingredients and intermediates in pharmaceutical and agrochemical industries
Flavor and fragrance ingredient in the food and beverage industry
Potential applications in the production of polymers and as a chemical intermediate in organic synthesis

Safety

Handle with care and follow proper safety protocols when using or handling.

Upstream product

• 57443-17-1 2-ethyl-4,4-dimethoxy-acetoacetic acid methyl ester 
• 124-41-4 sodium methylate 
• 116204-37-6 Acetic acid (Z)-1-formyl-but-1-enyl ester 
• 149-73-5 trimethyl orthoformate 
• 7647-01-0 hydrogenchloride 
• 62752-81-2 dimethyl hydrazone of pyruvic aldehyde dimethyl acetal 
• 1401816-27-0 N-trimethoxy-N-methyl-acetamide 
• 927-77-5 n-propylmagnesium bromide 
• 41718-50-7 2,2-dichloropentanal 
• 62752-73-2 1,1-dimethoxy-pentan-2-one dimethylhydrazone 

Downstream Products

• 18495-78-8 2-phenylhydrazono-valeraldehyde phenylhydrazone 

Relevant academic research and scientific papers

Efficient preparation of α-ketoacetals

The Weinreb amides 2a,b were prepared from the a,a-dimethoxyacetic acids 1c,d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded a-ketoacetals 3a-j in 70-99% yield. These compounds represent a versatile arrangement of functional groups of significant synthetic value, as demonstrated in the synthesis of (±)-salbutamol.

3-(2-Acylamino-1-Hydroxyethyl)-Morpholine Derivatives and Their Use as Bace Inhibitors

The present invention provides BACE inhibitors of Formula (I); methods for their use and preparation, and intermediates useful for their preparation.

Selective protection of the functionalities of α-hydroxy unsaturated aldehydes

The polyfunctionalized title compounds α-enol aldehydes are selectively protected either as ethylenic aldehyde acetates, ethylenic aldehyde sulfonates, ethylenic acetal sulfonates, or oxo acetal derivatives.