69592-33-2

Basic information

• Product Name: dihydrocilostaMide
• Synonyms: dihydrocilostaMide;N-CYCLOHEXYL-N-METHYL-4-((2-OXO-1,2,3,4-TETRAHYDROQUINOLIN-6-YL)OXY)BUTANAMIDE;Butanamide,N-cyclohexyl-N-methyl-4-[(1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)oxy]-
• CAS NO: 69592-33-2
• Molecular Formula: C₂₀H₂₈N₂O₃
• Molecular Weight: 344.44792
• Mol File: 69592-33-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: dihydrocilostaMide(CAS DataBase Reference)
• NIST Chemistry Reference: dihydrocilostaMide(69592-33-2)
• EPA Substance Registry System: dihydrocilostaMide(69592-33-2)

Safety Data

• Hazardous Substances Data: 69592-33-2(Hazardous Substances Data)

Upstream product

• 100-60-7 N-methylcyclohexylamine 
• 94193-38-1 N-Cyclohexyl-N-methyl-4-(3-formyl-4-nitrophenyl)-oxybutyramide 
• 94193-37-0 4-(3-Formyl-4-nitro-phenoxy)-butyryl chloride 
• 94193-36-9 4-(3-formyl-4-nitrophenyl)oxybutanoic acid 
• 105763-50-6 N-cyclohexyl-N-methyl-4-<3-(2-carboxyvinyl)-4-nitrophenoxy>butyramide 
• 94193-35-8 ethyl 4-((3-formyl-4-nitrophenyl)oxy)butyrate 
• 42454-06-8 2-nitro-5-hydroxybenzaldehyde 
• 105763-72-2 (E)-3-{2-Amino-5-[3-(cyclohexyl-methyl-carbamoyl)-propoxy]-phenyl}-acrylic acid 

Relevant articles and documents

Inhibitors of cyclic AMP phosphodiesterase. 1. Analogues of cilostamide and anagrelide

Evaluation of a series of lactam heterocyclic analogues of cilostamide as inhibitors of cyclic AMP phosphodiesterase derived from both human platelets and rat heart in comparison with their corresponding methoxy-substituted heterocycles has revealed that the N-cyclohexyl-N-methyl-4-oxybutyramide side chain of 2 is an important lipophilic and/or steric pharmacophore. Attachment of this side chain to the parent heterocycle of the potent cyclic AMP phosphodiesterase inhibitor anagrelide afforded the hybrid structure RS-82856, shown to be more potent than either of its progenitors as an inhibitor of cyclic AMP phosphodiesterase or of ADP-induced platelet aggregation. The available in vitro data suggest that 1 possesses potentially useful antithrombotic and cardiotonic properties.