6962-09-0

Usage

Uses

Used in Cosmetic Industry:
Ferulic acid is used as an antioxidant and preservative in the cosmetic industry for its ability to neutralize free radicals, which can cause damage to cells and contribute to aging and disease. Its presence in skincare products helps protect against environmental stressors and promotes skin health.
Used in Food Industry:
In the food industry, ferulic acid is utilized as a natural preservative to extend the shelf life of products by preventing oxidation and spoilage. Its antioxidant properties also help maintain the nutritional value and freshness of food items.
Used in Pharmaceutical Applications:
Ferulic acid is being investigated for its potential therapeutic applications in medicine, particularly in the areas of cardiovascular disease prevention and cancer treatment. Its antioxidant and anti-inflammatory properties may help protect against the development and progression of these diseases.
Used in Antioxidant Formulations:
Ferulic acid is used as a key component in antioxidant formulations to combat oxidative stress and support overall health. Its ability to neutralize free radicals and protect cells from damage makes it a valuable addition to dietary supplements and health products.

Upstream product

• 103-82-2 phenylacetic acid 
• 123-08-0 4-hydroxy-benzaldehyde 
• 587870-64-2 α-phenyl-p-isopropoxycinnamic acid 
• 51082-11-2 (E)-3-(4-acetoxyphenyl)-2-phenylacrylic acid 
• 18962-05-5 4-isopropoxybenzaldehyde 
• 879008-22-7 3c-(4-hydroxy-phenyl)-2-phenyl-acrylic acid 

Downstream Products

• 3839-46-1 (Z)-1-(4-hydroxyphenyl)-2-phenylethene 
• 178258-43-0 (R)-3-(4-Hydroxy-phenyl)-2-phenyl-propionic acid 
• 577-91-3 3-(4-hydroxy-3,5-diiodo-phenyl)-2-phenyl-propionic acid 
• 6968-77-0 3-(4-methoxyphenyl)-2-phenylacrylic acid 
• 89-23-6 3-(4-hydroxyphenyl)-2-phenylpropanoic acid 

Relevant academic research and scientific papers

Novel stilbene scaffolds efficiently targetMycobacterium tuberculosisnucleoid-associated protein, HU

Novel scaffolds of stilbene were identified as inhibitors ofMycobacterium tuberculosisby targeting the nucleoid-associated protein, HU, using molecular docking. Based on the proposed combinatorial libraries I to VI, structures I and III had significantly greater docking binding energy that was comparable to that of the reference ligand, protein HU, fromMycobacterium tuberculosis.Using these docking results, 18 compounds were synthesized, characterized and evaluated forin vitroantitubercular (anti-TB) efficacy in theMycobacterium tuberculosisstrain, H37Rv. Thein vitroscreening results indicated a significant positive correlation between the docking binding efficacy (r2> 0.5) and clogp. Compounds3f,3dand4fwere ranked as top scoring ligands that interacted with amino acids ARG 53, ARG 55, PRO 81, PHE 79, and LYS 13, where the -NO2or -Cl substitution at theparaposition of the 3-phenyl ring was essential for interacting of the HU protein. The hydrogen bonding with ARG 55 and LYS 13 of these compounds was similar to that with the reference ligand that inhibits the HUMtbprotein. Compounds3d,3f, and4fwere evaluated as active leads, with MIC90 values of 21.3, 23.2 and 44.1 μM, respectively. The above mentioned compounds were also evaluated for antibacterial and antifungal efficacy in a panel of selected bacteria and fungi. Compound3dhad efficacy (MIC90: 6.82 μM) inS. aureusandE. coli. Compound3fwas also efficacious inE. coliandA. Niger, with an MIC90 value of 7.42 μM for both microorganisms. The fluoro-phenyl derivatives,3iand4i, were efficacious inC. albicans(MIC90 values of 8.2 and 7.8 μM, respectively) andA. niger(MIC90 values of 4.1 and 3.1 μM, respectively). Our results suggest that substitutions at theparaposition of 3-phenyl acryl derivatives with -NO2and -Cl significantly affected the binding interactions with the HUMtb protein in the docking studies. Furthermore these compounds had antitubercular and antimicrobial efficacy. The substituted phenyl acrylic acid and hydrazides could be inhibitors of the HUMtb protein ofMycobacterium tuberculosis.

Antioxidant, anti-tyrosinase and anti-melanogenic effects of (E)-2,3-diphenylacrylic acid derivatives

During our continued search for strong skin whitening agents over the past ten years, we have investigated the efficacies of many tyrosinase inhibitors containing a common (E)-β-phenyl-α,β-unsaturated carbonyl scaffold, which we found to be essential for

Heterogeneous enantioselective hydrogenation of hydroxy-substituted (E)-2,3-diphenylpropenoic acids over Pd/Al2O3 modified by cinchonidine

The enantioselective hydrogenation of (E)-2,3-diphenylpropenoic acids substituted by hydroxyl group has been studied over Pd/Al2O 3 catalyst modified by cinchonidine. The effect of the acidic hydroxyl substituents was compared with that of the methoxy group in the same position. The para-hydroxyl substituent on the 3-phenyl ring had similar effect on the enantioselectivity as the methoxy group, whereas the meta positioned decreased the optical purity of the saturated acid. This was explained by different origin of the increase in the enantioselectivity obtained in the presence of electron releasing substituents in these positions. Although, the para-hydroxyl group on the 2-phenyl ring had beneficial influence on the enantioselectivity of the hydrogenation of the mono-substituted acid, in the presence of fluorine or hydroxyl group on the 3-phenyl ring the effect of the two substituents was not additive. This study demonstrated that the cinchonidine-modified Pd catalyst is appropriate for the preparation of several hydroxy-substituted 2,3-diphenylpropionic acids in good optical purities, extending the scope of this catalytic system to new types of versatile chiral building blocks.

A re-investigation of resveratrol synthesis by Perkins reaction. Application to the synthesis of aryl cinnamic acids

A re-investigation of resveratrol synthesis by Perkins reaction allowed to improve this method and to determine the configuration of the intermediates. The results were applied to the synthesis of several aryl cinnamic acids for biological evaluation.