89-23-6

Basic information

• Product Name: 3-(4-HYDROXYPHENYL)-2-PHENYLPROPIONIC ACID
• Synonyms: Nsc 60596;Propionic acid, 3-(p-hydroxyphenyl)-2-phenyl- (8ci);3-(4-hydroxyphenyl)-2-phenylpropanoic acid(SALTDATA: FREE);3-(4-Hydroxyphenyl)-2-phenylpropanoic acid;3-(P-HYDROXYPHENYL)-2-PHENYLPROPIONIC ACID;3-(4-HYDROXYPHENYL)-2-PHENYLPROPIONIC ACID;4-Hydroxy-α-phenylbenzenepropanoic acid;α-Phenyl-4-hydroxybenzenepropionic acid
• CAS NO: 89-23-6
• Molecular Formula: C₁₅H₁₄O₃
• Molecular Weight: 242.27
• EINECS: 201-888-4
• Mol File: 89-23-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 401.2 °C at 760 mmHg
• Flash Point: 210.6 °C
• Appearance: /
• Density: 1.253g/cm³
• Vapor Pressure: 3.7E-07mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(4-HYDROXYPHENYL)-2-PHENYLPROPIONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-HYDROXYPHENYL)-2-PHENYLPROPIONIC ACID(89-23-6)
• EPA Substance Registry System: 3-(4-HYDROXYPHENYL)-2-PHENYLPROPIONIC ACID(89-23-6)

Safety Data

• Hazardous Substances Data: 89-23-6(Hazardous Substances Data)

Usage

General Description

3-(4-Hydroxyphenyl)-2-phenylpropionic acid is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve pain and reduce inflammation. It works by inhibiting the production of certain chemicals in the body that are involved in the inflammatory response. This medication is commonly prescribed for conditions such as arthritis, menstrual cramps, and other sources of chronic pain. It is typically taken orally and may cause side effects such as stomach upset, headache, and dizziness. As with all medications, it is important to use 3-(4-Hydroxyphenyl)-2-phenylpropionic acid only as directed by a healthcare professional and to closely monitor for any adverse effects.

InChI:InChI=1/C15H14O3/c16-13-8-6-11(7-9-13)10-14(15(17)18)12-4-2-1-3-5-12/h1-9,14,16H,10H2,(H,17,18)/t14-/m0/s1

Upstream product

• 4314-68-5 3-(4-methoxyphenyl)-2-phenylpropionic acid 
• 123-08-0 4-hydroxy-benzaldehyde 
• 123-11-5 4-methoxy-benzaldehyde 
• 103-82-2 phenylacetic acid 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 577-91-3 3-(4-hydroxy-3,5-diiodo-phenyl)-2-phenyl-propionic acid 
• 879008-22-7 3c-(4-hydroxy-phenyl)-2-phenyl-acrylic acid 
• 6962-09-0 (E)-3-(4-hydroxyphenyl)-2-phenylacrylic acid 
• 6968-77-0 3-(4-methoxyphenyl)-2-phenylacrylic acid 

Downstream Products

• 57151-46-9 1-phenyl-2-[4-(phenylmethoxy)phenyl]-ethylamine 
• 854673-51-1 3-(4-benzyloxy-phenyl)-2-phenyl-propionic acid amide 
• 501031-62-5 3-(4-hydroxy-phenyl)-2-phenylpropionic acid methyl ester 
• 125036-76-2 3-(4-benzyloxy-phenyl)-2-phenyl-propionic acid 
• 577-91-3 3-(4-hydroxy-3,5-diiodo-phenyl)-2-phenyl-propionic acid 

Relevant articles and documents

Heterogeneous enantioselective hydrogenation of hydroxy-substituted (E)-2,3-diphenylpropenoic acids over Pd/Al2O3 modified by cinchonidine

The enantioselective hydrogenation of (E)-2,3-diphenylpropenoic acids substituted by hydroxyl group has been studied over Pd/Al2O 3 catalyst modified by cinchonidine. The effect of the acidic hydroxyl substituents was compared with that of the methoxy group in the same position. The para-hydroxyl substituent on the 3-phenyl ring had similar effect on the enantioselectivity as the methoxy group, whereas the meta positioned decreased the optical purity of the saturated acid. This was explained by different origin of the increase in the enantioselectivity obtained in the presence of electron releasing substituents in these positions. Although, the para-hydroxyl group on the 2-phenyl ring had beneficial influence on the enantioselectivity of the hydrogenation of the mono-substituted acid, in the presence of fluorine or hydroxyl group on the 3-phenyl ring the effect of the two substituents was not additive. This study demonstrated that the cinchonidine-modified Pd catalyst is appropriate for the preparation of several hydroxy-substituted 2,3-diphenylpropionic acids in good optical purities, extending the scope of this catalytic system to new types of versatile chiral building blocks.