6965-36-2

Upstream product

• 186581-53-3 diazomethane 
• 85644-03-7 4'-Hydroxy-5,6,7,8,3',5'-hexamethoxyflavone 
• 21187-73-5 gardenin A 
• 77-78-1 dimethyl sulfate 
• 29201-94-3 1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-1,3-propanedione 
• 151-10-0 1,3-Dimethoxybenzene 
• 25676-73-7 2,4,6-tribromo-1,3-dimethoxybenzene 
• 53887-77-7 2-hydroxy-3,4,5,6-tetramethoxybenzene 
• 13909-75-6 1,2,3,4,5-pentamethoxybenzene 

Downstream Products

• 21187-73-5 gardenin A 
• 117783-83-2 2,3,4,5-Tetramethoxy-6-[5-(3,4,5-trimethoxy-phenyl)-1H-pyrazol-3-yl]-phenol 
• 3162-28-5 2-hydroxy-3,4,5,6-tetramethoxyacetophenone 
• 29201-94-3 1-(2-hydroxy-3,4,5,6-tetramethoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-1,3-propanedione 
• 118-41-2 Eudesmic acid 
• 97564-57-3 3'-hydroxy-5,6,7,8,2',4',5'-heptamethoxyflavone 
• 97564-58-4 5,3'-dihydroxy-6,7,8,2',4',5'-hexamethoxyflavone 

Relevant academic research and scientific papers

Synthesis and Antiproliferative Activity of Natural and Non-Natural Polymethoxychalcones and Polymethoxyflavones

Two series of polymethoxychalcones and polymethoxyflavones, including the natural products 2′-hydroxy-3,4,5,4′,6′-pentamethoxychalcone (8c), 5,6,7,8,3′,4′,5′-heptamethoxyflavone (6), 5,7,3′,4′,5′-pentamethoxyflavone (9c), 3-hydroxy-5,6,7,8,3′,4′,5′-heptam

Use of flavone and flavanone derivatives in preparation of sedative and hypnotic drugs

Disclosed is a use of flavones derivatives and flavanone derivatives in preparation of sedative and hypnotic drugs.

USE OF FLAVONE AND FLAVANONE DERIVATIVES IN PREPARATION OF SEDATIVE AND HYPNOTIC DRUGS

Disclosed is a use of flavones derivatives and flavanone derivatives in preparation of sedative and hypnotic drugs.

Miscrowave-assisted efficient synthesis of polymethoxyacetophenones and natural polymethoxyflavones, and thier inhibitory effects on melanogenesis

Microwave, assisted Friedel-Crafts acetylation of polymethoxybenzenes with acetic anhydride in the presence of In(CF3SO3)3 under solvent-free conditions was achieved rapidly to give polymethoxyacetophenones in high yields. Microwave-assisted benzoylation of 2'-hydroxypolymethoxyacetophenones with polymethoxybenzoyl chlorides, followed by the rearrangement of the resulting benzoates and the final formation of natural polymethoxyflavones was achieved rapidly and efficiently. The polymethoxyflavones showed inhibitory effects on melanogenesis in human melanoma cells.

Isolation of 4,4'-Dimethoxy-trans-stilbene and Flavonoids from Leaves and Twigs of Vitex negundo Linn.

The leaves and twigs of Vitex negundo Linn. afford a stilbene derivative characterised as 4,4'-dimethoxy-trans-stilbene (1), along with five flavones, 5,6,7,8,3',4',5'-heptamethoxy (2), 5-hydroxy-6,7,8,3',4'-pentamethoxy (5-O-desmethylnobiletin) (3), 5-hydroxy-6,7,8,3',4',5'-hexamethoxy (gardenin A) (4), 5-hydroxy-6,7,8,4'-tetramethoxy (gardenin B) (5) and 5-hydroxy-7,3',4',5'-tetramethoxyflavone (corymbosin) (6).This is the first report of 1 as a natural product.Compound 1 has been converted into 3,6-dimethoxyphenanthrene (11).The flavones 2,5 and 6 undergo interesting rearrangements when treated with hydrazine hydrate to generate the pyrazoles 14, 15 and 16 respectively.

POLYOXYGENATED FLAVONES FROM AGERATUM CONYZOIDES

Key Word Index - Ageratum conyzoides; Asteraceae; 5,6,7-trimethoxy-3',4'-methylenedioxyflavone; 5,6,7,3'-tetramethoxy-4'-hydroxyflavone; 5,6,7,3',5'-pentamethoxy-4'-hydroxyflavone; polyoxygenated flavones.Twelve polyoxygenated flavones have been isolated from Ageratum conyzoides, three of which are new natural flavones, namely ageconyflavones A (5,6,7-trimethoxy-3',4'-methylenedioxyflavone), B (5,6,7,3'-tetramethoxy-4'-hydroxyflavone) and C (5,6,7,3',5'-pentamethoxy-4'-hydroxyflavone).The other nine compounds were identified as linderoflavone B, eupalestin, nobiletin, 5'-methoxynobiletin, 5,6,7,5'-tetramethoxy-3',4'-methylenedioxyflavone, sinensetin, 5,6,7,3',4',5'-hexamethoxyflavone, 5,6,7,8,3'-pentamethoxy-4'-hydroxyflavone and 5,6,7,8,3',5'-hexamethoxy-4'-hydroxyflavone.