6966-15-0

Usage

Structure

A cyclohexane ring with a carboxyl group (-COOH) attached to the second carbon, and a 4-methoxybenzoyl group (a benzoyl group with a methoxy substituent) attached to the same carbon.

Derivative of cyclohexanecarboxylic acid

It is a modified version of cyclohexanecarboxylic acid with the addition of a 4-methoxybenzoyl group.

Biological activity

It has potential biological activity that makes it useful in pharmaceutical research and development.

Potential applications

It may have applications in the treatment of various diseases and conditions, but further research is needed.

Building block for synthesis

Its chemical structure and properties make it a valuable building block for the synthesis of other more complex organic molecules.

Potential in drug discovery

The compound has potential in drug discovery and medicinal chemistry due to its unique structure and potential biological activity.

Upstream product

• 6966-15-0 cis-2-(4'-methoxybenzoyl)cyclohexane-1-carboxylic acid 
• 100-66-3 methoxybenzene 
• 13149-00-3 1,2-cis-cyclohexanedicarboxylic anhydride 
• 66107-29-7 4-methoxyphenyl triflate 

Downstream Products

• 6966-15-0 (+/-)-2t-(4-methoxy-benzoyl)-cyclohexane-r-carboxylic acid 
• 736992-13-5 2-(4'-methoxybenzyl)cyclohexane-1-carboxylic acid 
• 855425-02-4 2-(4'-methoxybenzyl)cyclohexane-1-carboxylic acid chloride 

Relevant academic research and scientific papers

Nickel-Catalyzed Desymmetrizing Cross-Electrophile Coupling of Cyclic Meso-Anhydrides

A Ni-catalyzed desymmetrizing cross-electrophile coupling of cyclic meso-anhydrides with aryl triflates has been successfully demonstrated. This is the only example using cyclic meso-anhydrides in cross-electrophile coupling reactions. A diverse array of valuable γ-keto acid building blocks can be generated under these conditions with excellent functional group tolerance and stereochemical fidelity.

Novel selective PDE4 inhibitors. 2. Synthesis and structure-activity relationships of 4-aryl-substituted cis-tetra- and cis-hexahydrophthalazinones

A series of 4-aryl-substituted cis-4a,5,8,8a-tetra- and cis-4a,5,6,7,8,8a-hexahydro-2H-phthalazin-1-ones with high inhibitory activity toward cAMP-specific phosphodiesterase (PDE4) was synthesized. To study structure-activity relationships various substituents were introduced to the 2-, 3-, and 4-positions of the 4-phenyl ring. Substitution at the 4-position of the phenyl ring was restricted to a methoxy group, probably due to unfavorable steric interactions of larger groups with the binding site. The introduction of many alkoxy substituents including distinct ring systems and functional groups was allowed to the 3-position. It was found that in general the cis-4a,5,8,8a-tetrahydro-2H-phthalazin-1-ones are more potent than their hexahydrophthalic counterparts, the best activity residing in (4-imidazol-1-yl-phenoxy)butoxy analogue 16o (pIC50 = 9.7).

An efficient and general method for ester hydrolysis on the surface of silica gel catalyzed by indium triiodide under microwave irradiation

Carboxylic esters are hydrolyzed to the corresponding carboxylic acids in high yields through a simple microwave assisted operation on the surface of silica gel moistened with few drops of water in presence of indium triiodide.

A New Redundant Rearrangement of Aromatic Ring Fused Cyclic α-Hydroxydithiane Derivatives. Synthesis of Aromatic Ring Fused Cyclic 1,2-Diketones with One-Carbon Ring Expansion

A new reaction involving rearrangement of aromatic ring fused cyclic dithiane alcohol by N-chlorosuccinimide in CH2Cl2-H2O to the corresponding one-carbon ring expanded 1,2-diketone has been developed. A wide range of structurally varied dithiane alcohols have been found to undergo this rearrangement in high yields. The general criteria and reaction mechanism for this rearrangement have also been worked out.