6966-29-6Relevant academic research and scientific papers
A substrate-based methodology that allows the regioselective control of the catalytic aminohydroxylation reaction
Han, Hyunsoo,Cho, Chang-Woo,Janda, Kim D.
, p. 1565 - 1569 (2007/10/03)
Analogous to the Sharpless osmium-catalyzed asymmetric dihydroxylation (AD) reaction, structure I is proposed as the catalytically active species for the asymmetric aminohydroxylation (AA) reaction. Based on this model, the regiochemistry of the reaction
Biotransformations with baker's yeast: pH effects on diastereoselectivity during α-hydroxy-β-ketoester reductions and carbon-carbon bond cleavages
Fadnavis,Kumara Vadivel,Bhalerao
, p. 2355 - 2359 (2007/10/03)
Baker's yeast mediated reduction of α-substituted-β-ketoesters lead to reduction of the carbonyl group with high enantiospecificity and diastereoselectivity at low pH (4.0-5.0, e.e. >99%, d.e. >90%) but cleavage of the C-C bond is observed at higher pH >8.0). Similar carbon-carbon bond cleavages are observed in the reactions of α-acetamido-β-ketoesters and acetamidocinnamic acid.
