6972-09-4Relevant academic research and scientific papers
HETEROBIFUNCTIONAL MOLECULES AS TEAD INHIBITORS
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Paragraph 0259-0260, (2021/09/11)
The invention relates to compounds and methods of using said compounds, as well as pharmaceutical compositions containing such compounds, for treating diseases and conditions mediated by TEAD, such as cancer.
Rapid synthesis of the core scaffold of crinane and haemanthamine through a multi-component approach
Massaro, Nicholas P.,Pierce, Joshua G.
supporting information, (2021/06/09)
A rapid synthesis of the core structures of crinane and haemanthamine has been developed, enabled by a multicomponent approach. This work constitutes a formal synthesis of crinane and sets the stage for access to both families of natural products and key
NOVEL COMPOUND For Organic light emitting diode AND COATING COMPOSITION FOR ORGANIC LAYER COMPRISING THE SAME
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Paragraph 0137; 0138; 0139; 0140; 0175; 0176; 0177; 0178, (2020/12/29)
Provided are a compound represented by chemical formula (1) and a coating liquid composition comprising the same. The above formula (1) is as described in the description of the invention.
IRAK DEGRADERS AND USES THEREOF
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Paragraph 00962; 004961-004962, (2020/06/19)
The present invention provides compounds, compositions thereof, and methods of using the same.
Stereoselective, Multicomponent Approach to Quaternary Substituted Hydroindole Scaffolds
Massaro, Nicholas P.,Pierce, Joshua G.
supporting information, p. 5079 - 5084 (2020/07/04)
The Amaryllidaceae alkaloids have been a target of synthesis for decades due to their complex architectures and biological activity. A central feature of these natural product cores is a quaternary substituted hydroindole heterocycle. Building off the fou
A 4 - mercapto -1 - butanol synthesis process
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Paragraph 0032; 0033; 0034, (2017/05/02)
The present invention discloses a 4-mercapto-1-butanol synthesis process, which comprises: 1) dissolving 1,4-butanediol and an acid-binding agent in an organic solvent I, adding a sulfonylation agent in a dropwise manner to carry out a sulfonylation reaction, carrying out extraction separation with dichloromethane, and carrying out washing, drying and concentration to obtain a colorless oil-like substance; and 2) dissolving the colorless oil-like substance obtained in the step 1) in an organic solvent II, adding a nucleophile to carry out a nucleophilic substitution reaction, and finally carrying out pressure reducing distillation to obtain the 4-mercapto-1-butanol. According to the present invention, the completely-new 4-mercapto-1-butanol synthesis route is provided, the used raw materials are easy to obtain, the operation is simple, the reaction conditions are not harsh, and good industrial values are provided.
Quinazoline Derivatives Useful as CB-1 Inverse Agonists
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Paragraph 0536-0537, (2016/04/20)
The present invention is directed to quinazoline derivatives, pharmaceutical compositions containing said derivatives and their use in the treatment of disorders and conditions mediated by the CB-1 receptor; more particularly, in the treatment of disorders and conditions responsive to inverse agonism of the CB-1 receptor. For example, the compounds of the present invention are useful in the treatment of metabolic disorders.
Novel compound capable of activating Nrf2, and pharmaceutical compositions comprising the same
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Paragraph 0077-0079, (2016/10/08)
The present invention provides a novel compound which can activate Nrf2 that is a transcription factor for expression of the quinone reductase gene. Therefore the compound is effective for inhibiting apoptosis and preventing and treating brain nerve disea
A practical and scalable process to selectively monofunctionalize water-soluble α,ω-diols
Zhang, Quanxuan,Ren, Hong,Baker, Gregory L.
supporting information, p. 3384 - 3386 (2014/06/09)
A practical protocol for rapid and scalable synthesis of monofunctionalized α,ω-diols using a simple and inexpensive THP ether protection/deprotection strategy was described. Use of inexpensive DHP source and ease to remove excess water-soluble α,ω-diols
RADIOHALOTHYMIDINES AND METHODS OF THEIR SYNTHESIS AND USE IN PET IMAGING OF CANCERS
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Page/Page column 18, (2008/06/13)
We disclose methods of synthesizing radiohalidated organic compounds and their use in positron emission tomography (PET) imaging of cancer cells. We also disclose specific N3 -radiohaloalkyl thymidines and salts thereof.
