69722-30-1Relevant academic research and scientific papers
H-phosphonate mediated sulfonylation of 2-substituted quinoline N-oxides: One-pot strategy for the synthesis of 3/4-sulfonylquinoline derivatives
Ma, Huili,Liu, Shuyun,Zhu, Shaohua,Bi, Wenzhu,Chen, Xiaolan,Zhao, Yufen
, p. 887 - 895 (2017/08/15)
series of biologically important 3/4-sulfonylquinoline derivatives was synthesized starting from easily available sodium benzenesulfinates, diethyl H-phosphonate and 2-substituted quinoline N-oxides in onepot under metal-free conditions. H-phosphonate plays a decisive role in activating the C3-H, C4-H bonds of the 2-substituted quinoline N-oxides. The isolated 3/4-sulfonylquinolines were characterized by 1H, 13CNMR spectroscopy and HR MS.
