69727-07-7

Basic information

• Product Name: (2Z)-3-(4-chlorophenyl)-2-cyanoprop-2-enoic acid
• Synonyms: (2Z)-3-(4-Chlorophenyl)-2-cyanoacrylic acid; 2-propenoic acid, 3-(4-chlorophenyl)-2-cyano-, (2Z)-
• CAS NO: 69727-07-7
• Molecular Formula: C₁₀H₆ClNO₂
• Molecular Weight: 207.6131
• Mol File: 69727-07-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 377°C at 760 mmHg
• Flash Point: 181.8°C
• Density: 1.415g/cm³
• Vapor Pressure: 2.36E-06mmHg at 25°C
• Refractive Index: 1.642
• CAS DataBase Reference: (2Z)-3-(4-chlorophenyl)-2-cyanoprop-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2Z)-3-(4-chlorophenyl)-2-cyanoprop-2-enoic acid(69727-07-7)
• EPA Substance Registry System: (2Z)-3-(4-chlorophenyl)-2-cyanoprop-2-enoic acid(69727-07-7)

Safety Data

• Hazardous Substances Data: 69727-07-7(Hazardous Substances Data)

Usage

General Description

The chemical "(2Z)-3-(4-chlorophenyl)-2-cyanoprop-2-enoic acid" is an organic compound with the molecular formula C11H8ClNO2. It consists of a 4-chlorophenyl group, a cyanopropenoic acid group, and a conjugated double bond system. (2Z)-3-(4-chlorophenyl)-2-cyanoprop-2-enoic acid is a derivative of propenoic acid and is commonly used in organic synthesis and chemical research. Its properties and potential applications are still under investigation, but it is likely to have uses in pharmaceuticals, agrochemicals, and materials science due to its unique structure and reactivity.

Upstream product

• 2286-35-3 ethyl 3-(4-chlorophenyl)-2-cyanoacrylate 
• 104-88-1 4-chlorobenzaldehyde 
• 372-09-8 cyanoacetic acid 
• 883024-88-2 tert-butyl-3-(4-chlorophenyl)-2-cyanoacrylate 

Downstream Products

• 54440-99-2 methyl 2-cyano-3-(4-chlorophenyl)propenoate 
• 126245-52-1 [(E)-3-(4-Chloro-phenyl)-2-cyano-acryloyl]-urea 
• 124-38-9 carbon dioxide 
• 28446-72-2 4-chlorocinnamonitrile 

Relevant articles and documents

Thiazolopyridines Improve Adipocyte Function by Inhibiting 11 Beta-HSD1 Oxoreductase Activity

Background. Glucocorticoid excess has been linked to clinical observations associated with the pathophysiology of metabolic syndrome. The intracellular glucocorticoid levels are primarily modulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme that is highly expressed in key metabolic tissues including fat, liver, and the central nervous system. Methods. In this study we synthesized a set of novel tetrahydrothiazolopyridine derivatives, TR-01-4, that specifically target 11β-HSD1 and studied their ability to interfere with the glucocorticoid and lipid metabolism in the 3T3-L1 adipocytes. Results. Based on the docking model and structure-activity relationships, tetrahydrothiazolopyridine derivatives TR-02 and TR-04 showed the highest potency against 11β-HSD1 by dose-dependently inhibiting conversion of cortisone to cortisol (IC50 values of 1.8 μM and 0.095 μM, resp.). Incubation of fat cells with 0.1-10 μM TR-01-4 significantly decreased cortisone-induced lipid accumulation in adipocytes and suppressed 11β-HSD1 mRNA expression. Observed reduction in adipocyte fat stores could be partially explained by decreased expression levels of adipogenic markers (PPAR-γ, aP2) and key enzymes of lipid metabolism, including fatty acid synthase (FAS), hormone sensitive lipase (HSL), and lipoprotein lipase (LPL). Conclusions. The tetrahydrothiazolopyridine moiety served as an active pharmacophore for inhibiting 11β-HSD1 and offered a novel therapeutic strategy to ameliorate metabolic alterations found in obesity and diabetes.

Proteomic approach based on MALDI-TOF MS to detect powdered milk in fresh cow's milk

Milk and cheese are expensive foodstuffs, and their consumption is spread among the population because of their high nutritional value; for this reason they are often subjected to adulterations. Among the common illegal practices, the addition of powdered

MALDI-TOF MS characterization of glycation products of whey proteins in a glucose/galactose model system and lactose-free milk

The major modifications induced by thermal treatment of whey proteins α-lactalbumin (α-La) and β-lactoglobulin (β-Lg) in a model system mimicking lactose-free milk (L- sugar mix) were investigated by matrix-assisted laser desorption ionization-