6973-01-9Relevant articles and documents
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Albert,Ohta
, p. 3727 (1971)
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A New Synthesis of 4-(Alkyl)aminopteridines (1,2)
Hara, Hiroshi,Plas, Henk C. van der
, p. 1527 - 1529 (2007/10/02)
On treatment of pteridine with potassium permanganate in liquid ammonia, 4-aminopteridine is obtained in good yield.The C4 ? adduct 4-amino-3,4-dihydropteridine is the intermediate species.Similarly, 2-chloropteridine undergoes amination at C4, yielding 4-amino-2-chloropteridine; thus no replacement of the chloro atom occurs.By this amination-oxidation procedure 4-ethylaminopteridine and its 2-chloro derivatives are also easily obtained.