6973-01-9Relevant academic research and scientific papers
4-Piperidinecarboxamide modulators of vanilloid VR1 receptor
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Page/Page column 52, (2010/11/08)
This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to hetero isonipecotic amides that are potent modulators of VR1 which are useful for the treatment and prevention of disease conditions in mammals.
A New Synthesis of 4-(Alkyl)aminopteridines (1,2)
Hara, Hiroshi,Plas, Henk C. van der
, p. 1527 - 1529 (2007/10/02)
On treatment of pteridine with potassium permanganate in liquid ammonia, 4-aminopteridine is obtained in good yield.The C4 ? adduct 4-amino-3,4-dihydropteridine is the intermediate species.Similarly, 2-chloropteridine undergoes amination at C4, yielding 4-amino-2-chloropteridine; thus no replacement of the chloro atom occurs.By this amination-oxidation procedure 4-ethylaminopteridine and its 2-chloro derivatives are also easily obtained.
SOME NEW SYNTHETIC APPROACHES FOR THE PREPARATION OF PTERIDINE-3-OXIDES AND PTERIDINES
Kocevar, Marjan,Stanovnik, Branko,Tisler, Miha
, p. 293 - 296 (2007/10/02)
Starting from 2-amino-3-cyanopyrazine some new syntheses of 4-substituted pteridines and pteridine-3-oxides have been devised.
