700-47-0

Usage

Uses

Used in Pharmaceutical Industry:
4-Hydroxypteridine is utilized as a precursor in the synthesis of biopterin for pharmaceutical applications. It is crucial for the production of several essential enzymes that are vital for various biological processes.
Used in Neurotransmitter Production:
In the field of neuroscience, 4-Hydroxypteridine is used as an intermediate in the biosynthesis of tetrahydrobiopterin, which is essential for the conversion of amino acids into neurotransmitters. This conversion is critical for maintaining proper neurological function and communication within the nervous system.
Used in Research and Development:
4-Hydroxypteridine is employed as a research compound in various scientific studies and experiments. It aids in understanding the role of pteridines and their derivatives in biological systems, as well as their potential applications in medicine and other fields.
Used in Diagnostic Applications:
In the medical and diagnostic industry, 4-Hydroxypteridine may be used as a biomarker to study and monitor certain physiological conditions or diseases. Its presence and levels in tissues and fluids can provide insights into the functioning of the enzymes and neurotransmitters it is involved in synthesizing.

InChI:InChI=1/C6H4N4O/c11-6-4-5(9-3-10-6)8-2-1-7-4/h1-3H,(H,8,9,10,11)

Upstream product

• 91-18-9 pteridine 
• 2311-91-3 monoperoxyphthalic acid 
• 32587-10-3 3-aminopyrazine-2-carboxamide 
• 122-51-0 orthoformic acid triethyl ester 
• 6973-01-9 4-aminopteridine 
• 14131-04-5 dimethyl-pteridin-4-yl-amine 
• 131543-46-9 Glyoxal 
• 1672-50-0 5,6-diamino-4(3H)-pyrimidinone 
• 30564-38-6 4-methoxy-pteridine 
• 76952-41-5 N-Pteridin-4-yl-hydroxylamine 
• 67-56-1 methanol 
• 86805-19-8 4-(N,N-dimethylaminomethyleneamino)pteridine 3-oxide 
• 34859-38-6 2-Cyano-3-<(dimethylaminomethylene)amino>pyrazine 
• 76952-40-4 4-aminopteridine 3-oxide 

Downstream Products

• 24851-65-8 3-methyl-3H-pteridin-4-one 
• 30564-38-6 4-methoxy-pteridine 
• 5424-01-1 3-aminopyrazinoic acid 
• 49539-13-1 5,6,7,8-tetrahydropteridin-4(3H)-one 
• 487-21-8 Lumazine 
• 72700-48-2 4-chloro-pteridine 
• 1268607-25-5 [2-(4-benzyloxyphenyl)-ethyl]-pteridin-4-yl-amine 

Relevant academic research and scientific papers

Electrochemical synthesis of quinazolinone: via I2-catalyzed tandem oxidation in aqueous solution

The development of protocols for synthesizing quinazolinones using biocompatible catalysts in aqueous medium will help to resolve the difficulties of using green and sustainable chemistry for their synthesis. Herein, using I2 in coordination with electrochemical synthesis induced a C-H oxidation reaction which is reported when using water as the environmentally friendly solvent to access a broad range of quinazolinones at room temperature. The reaction mechanism strongly showed that I2 cooperates electrochemically promoted the oxidation of alcohols, then effectively cyclizing amides to various quinazolinones.

Electro-oxidative cyclization: Access to quinazolinones: Via K2S2O8without transition metal catalyst and base

A K2S2O8-promoted oxidative tandem cyclization of primary alcohols with 2-aminobenzamides to synthesize quinazolinones was successfully achieved under undivided electrolytic conditions without a transition metal and base. The key feature of this protocol is the utilization of K2S2O8 as an inexpensive and easy-to-handle radical surrogate that can effectively promote the reaction via a simple procedure, leading to the formation of nitrogen heterocycles via direct oxidative cyclization at room temperature in a one-pot procedure under constant current. Owing to the use of continuous-flow electrochemical setups, this green, mild and practical electrosynthesis features high efficiency and excellent functional group tolerance and is easy to scale up.

RING TRANSFORMATIONS OF SOME 4-AMINOPTERIDINE 3-OXIDES AND DERIVATIVES

Syntheses of 4-aminopteridine 3-oxides are described.The pyrimidine part undergoes transformations with various reagents to give 4-hydroxyaminopteridines, substituted pyrazines, or substituted 1,2,4-oxadiazolylpyrazines. s-Triazolo(1,5-a)pyrazines can be prepared from 1,2,4-oxadiazolylpyrazines.The ring opening of the pyrimidine part of pteridines proceeds either py a C2-N3 or N3-C4 bond cleavage.

SOME NEW SYNTHETIC APPROACHES FOR THE PREPARATION OF PTERIDINE-3-OXIDES AND PTERIDINES

Starting from 2-amino-3-cyanopyrazine some new syntheses of 4-substituted pteridines and pteridine-3-oxides have been devised.