69736-76-1

Upstream product

• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 61-28-9 1-ethyl-1,3-dihydro-2H-indol-2-one 
• 106-40-1 4-bromo-aniline 
• 74-96-4 ethyl bromide 
• 66475-83-0 N-(4-bromophenyl)-2-(hydroxyimino) acetamide 
• 75-03-6 ethyl iodide 
• 41192-37-4 5-bromo-1-ethyl-2-indolinone 

Downstream Products

• 1219433-07-4 10'-amino-5-bromo-1,2-dihydro-1-ethyl-2,7'-dioxospiro[3H-indole-3,8'(7H,8H)-phenaleno[1,2-b]pyran]-9'-carbonitrile 
• 1221252-29-4 3-(5-amino-1,3-diphenyl-1H-pyrazol-4-yl)-5-bromo-1-ethyl-3-(2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-enyl)indolin-2-one 
• 1217110-07-0 5-bromo-1-ethyl-5'-(2-hydroxybenzoyl)-1',3'-diphenyl-5',7'-dihydrospiro[indoline-3,4'-pyrazolo[3,4-b]pyridine]-2,6'(1'H)-dione 
• 1354574-59-6 5'-bromo-1'-ethyl-1,4-dihydro-1,3-diphenylspiro[11Hbenzo[g]pyrazolo[4,3-b]quinoline-11,3'-[3H]indole]-2',5,10(1'H)-trione 
• 1354574-60-9 5'-bromo-10-ethyl-1,4-dihydro-1-(4-methoxyphenyl)-3-phenylspiro[11H-benzo[g]pyrazolo[4,3-b]quinoline-11,3'[3H]indole]-2',5,10(1'H)-trione 
• 1152724-62-3 1-ethyl-5-bromo-1',3'-diphenyl-spiro[indoline-3,4'-pyrazolo[4',3':5,6]pyrido[2,3-d]pyrimidine]-2,5',7'(6'H,8'H,9'H)-trione 
• 1040140-43-9 9-bromo-6-ethyl-2,3-difluoro-6H-indolo[2,3-b]quinoxaline 
• 870140-87-7 C₁₉H₁₈BrNO₃ 

Relevant academic research and scientific papers

A ribbon-like ultramicroporous conjugated polycarbazole network for gas storage and separation

A new ultramicroporous conjugated network, P-TCzTAT, enriched with propeller-like carbazole building blocks was designed and synthesized by FeCl3 oxidative coupling polymerization at room temperature. The adsorption isotherm of N2 reveals that the polymer features a high Brunauer-Emmett-Teller (BET) specific surface area of 1028 m2 g-1 and a predominantly narrow pore width of 0.54 nm. The ultramicroporous polymer has strong affinity for CO2, with high sorption abilities of 18.15% at 273 K and 1.1 bar and 10.69% at 273 K/1.1 bar and 298 K/1.1 bar, which can be ascribed to not only its optimal fraction of ultramicropores but also its high nitrogen content derived from the carbazole components. P-TCzTAT also exhibited potential application in gas storage and in CO2/CH4 and CO2/N2 gas separation.

Enantiopure [Cs+/Xe?Cryptophane]?FeII 4L4 Hierarchical Superstructures

Hierarchically nested hosts offer new opportunities to control the guest binding of the inner host, functionalize the cavity of the outer host, and investigate communication between different layers. Here we report a selfassembled triazatruxene-based FeII

Lanthanide Silylamide-Catalyzed Synthesis of Pyrano[2,3- b]indol-2-ones

A lanthanide silylamide-catalyzed tandem reaction of isatins, diethyl phosphite, and 2,3-diarylcyclopropenones has been developed. A series of pyrano[2,3-b]indol-2-ones were synthesized in high yields. The cooperation of the Lewis acidity of the lanthanide center and the Bronsted basicity of the N(SiMe3)2 anion may be the key factor affecting the catalytic activity of lanthanide amides.

Blue-orange emitting carbazole based donor-acceptor derivatives: Synthesis and studies of modulating acceptor unit on opto-electrochemical and theoretical properties

In order to demonstrate an effect of varying acceptor unit on optoelectronic properties of Donor–Acceptor (D–A) assembly, we herein designed and synthesized C–N coupled, carbazole based dyes 1–8 by employing Buchwald–Hartwig coupling amination reaction and fully characterized by spectroscopic methods. Presence of intramolecular charge transfer (ICT) transitions (λmax = 403–467 nm) in absorption spectra of all dyes reminiscent D–A assembly in it and emit in blue–yellow region (λemm = 467–565 nm) in solution state with marked positive solvatochromism. The photophysical studies of some of the dyes in different THF/water mixtures revealed aggregation-induced emission (AIE) feature with the nanoparticles formation, as confirmed by dynamic light scattering (DLS) technique. The HOMO (?5.42 to ?5.74 eV) and LUMO (?3.03 to ?3.50 eV) energy level of these molecules measured by cyclic voltammetry suggest electron transporting property in it. Further, DFT/TDDFT calculation of dyes, indicate quite comparable theoretical and experimental photophysical and electrochemical data. Moreover, calculated singlet (S1) and triplet (T1) excitation energy levels by DFT/B3LYP/6–311 G+(d,p) shows small ΔEST value for some dyes and hence called as TADF emitters. Thus obtained all optoelectrochemical properties of dyes propose its potential use in optoelectronic devices and in biosensing.

3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights

Herein we describe the design and synthesis of two series of sulfonamides featuring N-unsubstituted (4a-c) or N-substituted (7a-o) isatin moieties (as tails) connected to benzenesulfonamide moiety via a hydrazine linker. All the prepared sulfonamides (4a-c and 7a-o) showed potent inhibitory activities toward transmembrane tumor-associated human (h) carbonic anhydrase (hCA, EC 4.2.1.1) isoforms, IX and XII with KI range (8.3–65.4 nM) and (11.9–72.9 nM), respectively. Furthermore, six sulfonamides (7e, 7i, 7j, 7m, 7n and 7o) were assessed for their anti-proliferative activity, according to US-NCI protocol, toward a panel of sixty cancer cell lines. Compounds 7j and 7n were the most promising counterparts in this assay displaying broad spectrum anti-proliferative activity toward diverse cell lines. Also, sulfonamide 7n significantly inhibited clonogenicity of HCT-116 cells in a concentration dependent manner in the colony forming assay. Moreover, molecular modeling studies were performed to gain insights for the plausible binding interactions and affinities for the target isatin-based sulfonamides (4a-c and 7a-o) within hCA isoforms II and IX active sites.

PYRIDINONE DERIVATIVES AND THEIR USE AS SELECTIVE ALK-2 INHIBITORS

The invention relates to a compound of Formula I or a pharmaceutically acceptable salt thereof, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Triazino indole-quinoline hybrid: A novel approach to antileishmanial agents

A novel series of 1,2,4-triazino-[5,6b]indole-3-thione covalently linked to 7-chloro-4-aminoquinoline have been synthesized and evaluated for their in vitro activity against extracellular promastigote and intracellular amastigote form of Leishmania donovani. Among all tested compounds, compounds 7a and 7b were found to be the most active with IC50 values 1.11, 0.36 μM and selectivity index (SI) values 67, >1111, respectively, against amastigote form of L. donovani which is several folds more potent than the standard drugs, miltefosine (IC50 = 8.10 μM, SI = 7) and sodium stibo-gluconate (IC50 = 54.60 μM, SI ≥ 7).

Design and synthesis of 3-substituted indolin-2-one derivatives with methyl (e)-2-(3-Methoxy) acrylate moiety

In this article, fifteen indolin-2-one derivatives with methyl (E)-2-(3-methoxy)acrylate group were designed and synthesized. The structures of target compounds were confirmed by 1H NMR, IR and HR-MS spectra analysis.

Spirooxindole-derived morpholine-fused-1,2,3-triazoles: Design, synthesis, cytotoxicity and apoptosis inducing studies

A series of new spirooxindole-derived morpholine-fused-1,2,3-triazole derivatives has been synthesized from isatin spiro-epoxides. The protocol involves regiospecific isatin-epoxide ring opening with azide nucleophile followed by sequential O-propargylation, and intramolecular 1,3-dipolar cycloaddition reaction. These compounds have been evaluated for their antiproliferative activity against selected human tumor cell lines of lung (A549), breast (MCF-7), cervical (HeLa), and prostate (DU-145). Among the tested compounds, 6i, 6n and 6p showed potent growth inhibition against A549 cell line with IC50 values in the range of 1.87-4.36 μM, which are comparable to reference standards doxorubicin and 5-flourouracil. The compounds 6i and 6p treated A549 cells displayed typical apoptotic morphological features such as cell shrinkage, nuclear condensation, fragmentation, and decreased migration potential. Flow-cytometry analysis revealed that the compounds arrested the cells in G2/M phase of cell cycle. Hoechst and acridine orange/ethidium bromide staining studies also showed that the cell proliferation was inhibited through induction of apoptosis. Moreover, the compounds treatment led to collapse of the mitochondrial membrane potential (DΨm) and increased levels of reactive oxygen species (ROS) were noted in A549 cells.

Direct amidation of 2'-aminoacetophenones using I2-TBHP: A unimolecular domino approach toward isatin and iodoisatin

Synthesis of isatin and iodoisatin from 2'-aminoacetophenone was achieved via oxidative amido cyclization of the sp3 C-H bond using I 2-TBHP as the catalytic system. The reaction proceeds through sequential iodination, Kornblum oxidation, and amidation in one pot. This method is simple, atom economic, and works under metal- and base-free conditions.