698367-00-9

Upstream product

• 42412-18-0 3-phenylhydrazono-butyronitrile 
• 79-04-9 chloroacetyl chloride 
• 59-88-1 phenylhydrazine hydrochloride 
• 497084-16-9 (Z)-3-amino-2-(2-chloroacetyl)but-2-enenitrile 
• 100-63-0 phenylhydrazine 
• 64-17-5 ethanol 
• 64-19-7 acetic acid 

Downstream Products

• 861585-35-5 5-aminomethyl-3-methyl-1-phenyl-1H-pyrazole-4-carbonitrile 
• 1448812-06-3 N-(3-chloro-5-(((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino)methyl)-2-hydroxyphenyl)propionamide 
• 1448812-05-2 C₂₂H₁₉ClN₄O₂ 
• 1448812-10-9 C₂₉H₂₅ClN₄O₂ 
• 1448812-07-4 ((4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)methyl)triphenylphosphonium chloride 

Relevant academic research and scientific papers

Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents

The structure-activity relationship of phenylpyrazole derivative 1 was investigated for the development of novel anti-HIV agents. Initial efforts revealed that the diazenyl group can be replaced by an aminomethylene group. In addition, we synthesized various derivatives by the reductive amination of benzaldehydes with 5-aminopyrazoles and carried out parallel structural optimization on the benzyl group and the pyrazole ring. This optimization led to a six-fold more potent derivative 32j than the lead compound 1, and this derivative has a 3′,4′-dichloro-(1,1′-biphenyl)-3-yl group.

A short and expeditious regiospecific synthesis of novel pyrazoles

α-Cyano-β-enaminones, obtained by regioselective acylation of β-aminocrotononitrile, are smoothly and regiospecifically converted into substituted pyrazoles in good to excellent yields.